4legre, RS, Brasil .$BSTR.xT.-The review presents a glossary of the bisbenzylisoquinoline a k aloids. The following information is tahulated: structural formulas of all the bisbenzj-lisoquinoline alkaloids (BBI) with their molecular formulas: molecular n-eights: mp and : a ]~ values: uv, ord, nnir, mass data: degradation methods applied to determine their striictures: and sourres. -i list of the plants n-ith the particular part studied and the BBI alkaloidis) isolated from each source is furnished. In addition, this article summarizes the distribution of different t>-pes of BBI alkaloids in differenf genera, methods of isolation, and degradative techniques applied for structure elucidation.Since the days of the earliest commercial drug preparations, viz., R a d i i pareira bratae, Bebeeriiim pirrum and Curare (the arron-poison of South A%merican Indians), natural products chemists and pharmacognosists have been interested in the bisbenzylisoquinoline (BBI) alkaloid-because of their diverse formulations and varied pharniacological effects. Several reviews on the BBIs are already available (1-Sa). The article by Shamma ( 7 ) covers different chenlical aspects of thi. field and has intensified the long-felt need for a glossary of these alkaloids containing all information nece.sarj-for a natural product chemist searching for nen-BBI alkaloid-.BBI alkaloids are built up of tn-o benzylisoquinoline (BI) units linked by ether bridges. In addition to this ether linkage. methr lenosy bridging or direct carbon carbon bonding is also found between the two BI units. A variety of structural patterns arise in the BBI molecules due to differences in (1.) the number of aromatic oxygen subqtituent-present ; (2.) the number of ether linkage>; (3.) the nature of ether bridges, viz., diphen! 1 ether or benzylphenyl ether: and (4.) the sites on the tn-o BI unit-at n hich the ether or the carbon carbon bond originates. Based on these differences. the BBI alkaloids are claqsified into the groups and subgroups as shon n in table 1.Individual members in each group differ simplJ-in (1.) the nature of the osygenated substituents (OH, OMe, OCH,O) : (2.) the nature of substitution of the t n o nitrogen atonis ISH. S l l e , S -l I e r 3 S O ) ; (3.) the degree of unsaturation of the hetero ring.: and (4.) the stereochemistrj-of the tu-o asymmetric centers. BOTAA ICAL bocmE.-DiW-ibution of the different groups of BBI alkaloids in different genera and the botanical sources of these alkaloids are depicted in tables 2 and 3 respectively. Ecological factors affect the nature and amount of BBI alkaloids in plants. Cissampelos pareira Linn. from Kashmir yielded h a p t i n e (So. 1 3 i ,table 4) and hayatinine (So. 138. table 4) (both S S I type); xhereas a plant from Pilibhit yielded hayatine and curine ( S o . 133, table 4) (=.anie type), but no hayatinine (10); the plants from lladra. and Madagascar contained, in addition to hayatine and curine, isocliondodendrine ( S o . 122. table 4) (S type), which was not found in the extracts from Pilibh...

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