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suggests that dopaminergic neurons, the cell type lost in Parkinson's disease, are continuously generated in the adult substantia nigra pars compacta. Using similar methodological procedures to label dividing cells, we found no evidence of new dopaminergic neurons in the substantia nigra, either in normal or 6-hydroxydopamine-lesioned hemi-Parkinsonian rodents, or even after growth factor treatment. Furthermore, we found no evidence of neural stem cells emanating from the cerebroventricular system and migrating to the substantia nigra. We conclude that it is unlikely that dopaminergic neurons are generated in the adult mammalian substantia nigra.

The fast Fourier transform (FFT) technique is a very powerful tool for the efficient evaluation of gravity field convolution integrals. It can handle heterogeneous and noisy data, and thus presents a very attractive alternative to the classical, time consuming approaches, provided gridded data are available. This paper reviews the mathematics of the FFT methods as well as their practical problems, and presents examples from physical geodesy where the application of these methods is especially advantageous. The spectral evaluation of Stokes', Vening Meinesz' and Molodensky's integrals, least-squares collocation in the frequency domain, integrals for terrain reductions and for airborne gravity gradiometry , and the computation of covariance and power spectral density functions are treated in detail. Numerical examples illustrate the efficiency and accuracy of the FFT methods.

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