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EEG data obtained from 27 patients with presenile Alzheimer's disease (AD) and 28 patients with senile dementia of the Alzheimer type (SDAT) were compared with data from 30 age‐ and sex‐matched controls. Both patient groups exhibited more pronounced delta and theta activity and less prominent alpha and beta activity than the controls. AD, however, was accompanied by more severe slowing than SDAT. The slowing was distributed in the left temporal and frontal regions in AD, and bilaterally in the frontal regions in SDAT. As the severity of the dementia increased, delta activity alone increased in AD, whereas, there were significantly greater increases in both delta and theta activity and decreases in alpha and beta activity in SDAT. These EEG differences appear to be related to the degree of brain damage and the speed of progression of the disease process.

We undertook routine EEG, Z‐map, CT and PET scans in seven acute untreated schizophrenics. Routine EEGs showed slower activity in only one case. However, the Z‐map showed slower activity in all the cases. CT demonstrated brain atrophy in three of the cases, and PET revealed hypofrontality in two, right hypoparietality in four, and both conditions in one case. There was no relation between CT and PET or the Z‐map. However, a significant increase in alpha 1 activity was demonstrated on the Z‐map in cases who were found to be the parietal type on PET; this was not conspicuous in the frontal type on PET. Moreover, in three of the patients, the Z‐map findings were similar to the lesion indicated on PET.

As an ill effect of anticonvulsants after a long-term treatment, osteo-metabolic abnormality was noticed, and yet no full clarification has been made. Recently, we have measured the Vitamin D 3-fraction: 25-OHD,, 1-25 (OH)2D3, 24-25 (OH),D, and quantified the atrophic lesion of the bone by the microdensitometry method (hereinafter called MD method) for the outpatients, and found some interesting findings as follows. Materials and Methods

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