Objective-Recent studies have demonstrated that lymphovascular space invasion (LVSI) is associated with increased risk of hematogenous and lymphatic metastasis and poor clinical outcome of women with epithelial ovarian cancer. Given the suspected role of estrogen in promoting ovarian cancer metastasis, we examined potential links between estrogen receptor and LVSI in high-grade serous ovarian carcinoma.Methods-Tumoral expression of ER, PR, p53, MDR1, EGFR, HER2, DNA ploidy, and S-phase fraction was examined for 121 cases of stage I-IV high-grade serous ovarian carcinoma samples obtained at primary cytoreductive surgery. Biomarker expression was correlated to LVSI and survival outcomes.Results-LVSI was observed in 101 (83.5%) of all cases. Immunohistochemistry of tested biomarkers showed ER (86.7%) to be the most commonly expressed followed by p53 (71.4%), Conclusion-Our data demonstrated that estrogen receptor was positively correlated with LVSI that was an independent prognostic indicator of poor survival outcomes of high-grade serous ovarian carcinoma. This study emphasizes the importance of estrogen pathway in promoting lymphatic or vascular spread of high-grade serous ovarian carcinoma.

Additions to the Spectra Lila, Lizb and LiZla.Six new spectral lines have been observed in the lithium spectrum between 200 nm and 600 nm. Possible classifications are given and discussed.

The effects of wall charge on firing voltage, V f, and the statistical delay time of discharge, t s, in plasma display panels were investigated. V f, i.e., the ion-induced secondary electron emission, is independent of both the polarity and amount of wall charge. In contrast, t s, i.e., the exoelectron emission, strongly depends on the wall charge and is smaller for a high positive wall charge, revealing the coexistence of trapped electrons and holes in the surface region. Positive charging of the MgO surface of the cathode side is effective to improve the response of the address discharge.

An experimental approach was proposed for the measurement of the surface potential (SP) induced on an insulator surface during ion irradiation by ion scattering spectroscopy (ISS). The resultant ISS spectra obtained for a MgO thin film of 600nm thickness on a Si substrate under 950eV He+ irradiation revealed that the surface is positively charged by approximately 230V. In addition, the onset energy of a secondary ion peak indicated a SP of approximately 205V. The present results confirmed that ISS is an effective technique for measuring the SP during ion irradiation.