Angiosarcoma of the thyroid is a rare and aggressive primary malignant tumor of the thyroid: It rarely occurs in that organ and most of these occur mainly in patients from the mountainous Alpine regions.We report a case of 68 years old female who presented at our hospital with a rapidly enlarging neck mass associated with compressive symptoms. On clinical examination, the thyroid gland appeared firm during the acts of deglutition. The results of thyroid function tests were for subclinical hyperthyroidism. Ultrasound examination and CT scan showed multinodular goitre with a suspicious nodule from the right thyroid lobe. Fine needle aspiration cytology of the thyroid was suggestive of anaplastic thyroid carcinoma. A total thyroidectomy was performed. Grossly, the right lobe and left lobe measured 8×7×4 cm, and 8×8×7 cm. Macroscopically the cut surface showed a bulging solid hemorrhagic dark red mass, measuring 4.8×3.2×2.5 cm, at the lower pole of the right lobe. The immunohistochemistry showed CD31 and CD34 positivity and thyroglobulin, calcitonin, and TTF-1 negativity indicating an angiosarcoma. The patients died within 2 months following up from pulmonary hemorrhage. CONCLUSIONThis case illustrates that Thyroid angiosarcoma is a distinct entity and should be considered and included as a differential diagnosis of poorly differentiated thyroid neoplasm's also outside the mountainous Alpine regions.

No abstract

Thyroid cancer is a very common malignancy and fastest increasing of all cancer all over the world Differentiated thyroid cancer (DTC) in general has a good prognosis when ist diagnosed early. Late stage disease with Bone metastasis may cause severe complications, increases mortality rate, decreases the quality of life, and shortens the patients' survival. The treatment is still controversial. Surgery or radioiodine therapy alone is usually unsatisfactory, thus the management needs multidisciplinary collaboration.

No abstract

Hashimoto's thyroiditis (HT) is found in a high proportion of resected thyroid specimens. There has been considerable controversy as to whether having HT predisposes a patient to papillary thyroid cancer (PTC) and conflicting data have been reported with regard to Hashimoto thyroiditis (HT) and risk of malignancy. The aim of this study was to evaluate coexistence of papillary thyroid cancer (PTC) with HT.Materials and methods: This is a retrospective study done at American Hospital 2 from April 2011 until December 2013. We analyzed the data from 71 patients who underwent thyroid surgery at our institution. Of these, 29 patients were diagnosed with PTC. All patients diagnosed with PTC were evaluated for the presence of HT by measuring thyroid autoantibodies. If a patient had at least one positive thyroid autoantibody, then the patient was defined as having HT.Results: From a total of 71 patients who underwent thyroid surgery there were 29 patients diagnosed with PTC 3 males (10.3 % ) and 26 females ( 89.7 %), mean age 41.9 (age 18-73) years old. Thyroid antibodies Ac Anti TPO and Ac Anti Thyroglobulin were measured in all patients with PTC. They were positive in six patients with PTC (20.6.8 %). They were all female patients.Conclusion: These data demonstrate that HT is associated with an increased risk of developing PTC. We also observed a high ratio of females diagnosed with PTC compared with males. An adequate follow up of patients with Hashimoto's thyroiditis may permit an early diagnosis of differentiated thyroid cancer and its appropriate management. More prospective