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Pharmacovigilance plays an vital role in modern technology which helps in monitoring and assessing the high-quality of Drugs, detection and stopping of any unfavorable outcomes of drugs. Pharmacovigilance starts with case processing: this involve safety data collection and coding, case management reporting and submission. In case of clinical trial, it is the investigator or in case of post-marketing trial, it is either the physician or the prescriber or the patient himself who reports the adverse event or any drug-related problem. Pharmacovigilance case processing helps to get clear information regarding the drug and outcomes by using various software technologies. Arugs database, cemflow, vigibase and ICSR are few software used nowadays. Case processing helps to monitor and track all serious adverse events, and medically significant ADRs and other medical related product information followed by timely processing and reporting of such information according with company and regulatory reporting.

Terminalia chebula Retz (T.chebula) which is a member of the Combretaceae family is frequently used medicinal herb in Ayurvedic, Unani, Siddha & Homeopathy system of medicine. Terminalia chebula is called the "King of Medicine" in Tibet and is always listed at the top of the list in Ayurvedic Materia Medica due to its extraordinary power of healing. To evaluate the neuroprotective activity of Terminalia chebula Retz against ethanol induced cognitive impairment and oxidative stress in rats brain. The learning and memory enhancing activity of Terminalia chebula Retz extract were investigated in Sprague Dawley rats for 21 days and its effects on learning and memory were examined by using 8-arm radial maze (or) radial arm maze (RAM) and histopathological studies. All the groups showed significantly (P value is<0.0001) decrease in the time taken to reach paired arm (sec) & number of entries in baited arms and non-baited arms as compared to ethanol inducing group and histopathological study of Terminalia chebula showed significant effect when compared to the standard drug for treating Alzheimer's disease. Therefore Terminalia chebula was proved to be effective agent for treating Alzheimer's. The present study suggests Terminalia chebula that modulate the oxidative stress and be involved in the protective effect against oxidative damage and neurodegenerative diseases in rat.

Duloxetine  is an anti-depressant drug which is used in depression. The aim of present investigation was to prepare an ER tablet of duloxetine with similar dissolution profile matching to Effexor ER. An immediate release core tablet of 100mg was prepared and it was compression coated using HPMC matrix system. HPMC of three viscosity grades i.e., K4M, K15M, K100M and different concentrations of 15% polymer, 25% polymer, 35% polymer & 45% polymer were taken. With the above polymers by using wet granulation and direct compression process 11 formulations were prepared. The data obtained from in vitro drug release was used to determine the similarity factor between marketed and optimized product. Out of all F11 formulation (K15M 35% polymer) is optimized and is matching with the marketed product.