Pharmacological Evaluation of Leaf Extract of Terminalia bellerica with Moringa oleifera for its Synergistic Action on Anti-diabetic Activity and Anti-inflammatory Activity in Rats

Sk, Karishma; Lakshmi, K. S.; Tony, D. Eswar; Babu, A. Narendra; Nadendla, Rama Rao

doi:10.5958/0974-360x.2019.00195.1

Cited by 10 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The leaves are also used to treat wounds, fever, sores, bronchitis, eye, and ear infections [41]. Moreover, several studies have shown that the aqueous extracts of M. oleifera leaves possess a wide range of biological actions including antioxidant, tissue protective, cardioprotective, hepatoprotective, neuroprotective [42,43], analgesic [44], diuretic [45], antiulcer [46], anticancer [18], antidiabetic, anti-inflammatory [47], antimicrobial [48], antihypertensive [49], radioprotective [50,51], and immunomodulatory [52,53] effects. Furthermore, it was reported that the administration of an aqueous extract of M. oleifera leaves or seeds manifested potent antihyperglycemic [54,55] and antihyperlipidemic [39,56] effects in insulin-resistant and insulin-deficient rat models [30,57].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antidiabetic Effect of Combined Leaf and Seed Extracts of Moringa oleifera (Moringaceae) on Alloxan-Induced Diabetes in Mice: A Biochemical and Histological Study

Aljazzaf,

Regeai,

Elghmasi

et al. 2023

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Moringa oleifera (Moringaceae) is a medicinal plant rich in biologically active compounds. The aim of the present study was to screen M. oleifera methanolic leaf (L) extract, seed (S) extract, and a combined leaf/seed extract (2L : 1S ratio) for antidiabetic and antioxidant activities in mice following administration at a dose level of 500 mg/kg of body weight/day. Diabetes was induced by alloxan administration. Mice were treated with the extracts for 1 and 3 months and compared with the appropriate control. At the end of the study period, the mice were euthanized and pancreas, liver, kidney, and blood samples were collected for the analysis of biochemical parameters and histopathology. The oral administration of the combined L/S extract significantly reduced fasting blood glucose to normal levels compared with L or S extracts individually; moreover, a significant decrease in cholesterol, triglycerides, creatinine, liver enzymes, and oxidant markers was observed, with a concomitant increase in antioxidant biomarkers. Thus, the combined extract has stronger antihyperlipidemic and antioxidant properties than the individual extracts. The histopathological results also support the biochemical parameters, showing recovery of the pancreas, liver, and kidney tissue. The effects of the combined L/S extracts persisted throughout the study period tested. To the best of our knowledge, this is the first study to report on the antidiabetic, antioxidant, and antihyperlipidemic effects of a combined L/S extract of M. oleifera in an alloxan-induced diabetic model in mice. Our results suggest the potential for developing a natural potent antidiabetic drug from M. oleifera; however, clinical studies are required.

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of Antidiabetic Effect of Combined Leaf and Seed Extracts of Moringa oleifera (Moringaceae) on Alloxan-Induced Diabetes in Mice: A Biochemical and Histological Study

Aljazzaf,

Regeai,

Elghmasi

et al. 2023

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

Synthesis of New Iron Nanoparticles derived from Beta Vulgaris Extract and its Bioactivity against Enterobacter cloacae, Anti-inflammatory and House Fly

Hameed

Mohammad

Ahmed

et al. 2021

RJPT

View full text Add to dashboard Cite

Objective: This study aimed to synthesize a new iron nanoparticles derived from beta vulgaris extract and test its bioactivity against certain microbes. Materials and Methods: preparation of extract and the nanoparticles were done using certain procedures, while the Identification of Entero cloacae VITEK-2 ID-GN and AST-N 020 cards correspondingly applied for detection and susceptibility tests direct as of positive BacT/ALERT FA and FN blood cultures. Antibiotic susceptibility testing and anti bacterial as well as anti inflammatory activity, inhibition of protein denaturation and anti oxidant efficiency were achieved using AFM, UV-Visible and other instruments. Results: the presence of antioxidants, antibacterial and anti-inflammatory materials in nanoparticles were much more than in the extract. Conclusions: iron nanoparticles show much more activity against bacteria, oxidant and inflammatory agents.

show abstract

The Potency of Lactobacillus fermentum and Moringa oleifera Extract with different Fermentation Time to improve the Nutrient content of Fermented Rice Bran

Lokapirnasari

Maslachah

Sahidu

et al. 2022

RJPT

View full text Add to dashboard Cite

The aim of the study was to evaluate Lactobacillus fermentum (L.fermentum) and Moringa oleifera (M.oleifera) extract for the future development synbiotic to improve the nutrient content of rice bran fermented products to support health. The treatments are divided into 7 treatments: 1:control (without probiotic and without M.oleifera extract); 2:(1% L. fermentum); 3:(1% L. fermentum + 1% M.oleifera extract); 4:(1% L. fermentum + 2% M.oleifera extract); 5:(2% L. fermentum; 6:(2% L. fermentum + 1% M.oleifera extract); 7:(2% L. fermentum + 2% M.oleifera extract), and then incubated at 37ºC, 24 hours. Isolate L. fermentum (108 cfu/ml) which has been incubated with M. oleifera extract, then sprayed on the rice bran according to the each treatment, then incubated an aerob condition for 5 and 10 days. After the fermentation period was complete, a proximate analysis was carried out. Results: The addition of L. fermentum and M.oleifera extract could increase the crude protein content from 12.66% to 15.94% (2% L.fermentum + 2% M.oleifera extract on 5 days of fermentation), decrease crude fiber from 21.28% to 13.50% (2% L.fermentum + 1% M.oleifera extract on 5 days of fermentation), increase nitrogen free extract (NFE) from 43.81% to 51.53% (2% L.fermentum + 1% M.oleifera extract on 5 days of fermentation), increase metabolizable energy (ME) from 3006.97 kcal/kg to 3294.96 kcal/kg (1% L.fermentum + 1% M.oleifera extract, on 5 days of fermentation). The addition of 1% and 2% L.fermentum as probiotic and 1% and 2% Moringa oleifera extract as prebiotic had potential properties as synbiotic.

show abstract

Pharmacological Evaluation of Leaf Extract of Terminalia bellerica with Moringa oleifera for its Synergistic Action on Anti-diabetic Activity and Anti-inflammatory Activity in Rats

Cited by 10 publications

References 0 publications

Evaluation of Antidiabetic Effect of Combined Leaf and Seed Extracts of Moringa oleifera (Moringaceae) on Alloxan-Induced Diabetes in Mice: A Biochemical and Histological Study

Evaluation of Antidiabetic Effect of Combined Leaf and Seed Extracts of Moringa oleifera (Moringaceae) on Alloxan-Induced Diabetes in Mice: A Biochemical and Histological Study

Synthesis of New Iron Nanoparticles derived from Beta Vulgaris Extract and its Bioactivity against Enterobacter cloacae, Anti-inflammatory and House Fly

The Potency of Lactobacillus fermentum and Moringa oleifera Extract with different Fermentation Time to improve the Nutrient content of Fermented Rice Bran

Contact Info

Product

Resources

About