The literature has shown that low-level laser therapy accelerates the repair of cutaneous wounds. However, there is a scarcity of scientific studies that characterise the possible systemic interference of laser photobiomodulation. The aim of this research was to quantitatively evaluate blood corticosterone levels and tissue cytokine expression in cutaneous wounds of rats treated with low-level laser therapy (semiconductor diode AsGaAl, continuous emission, 9 mW, 670 nm, 0.031 W/cm(2), beam with an output area of 0.28 cm(2)) and normal controls. A total of 36 male Wistar rats were used and randomly divided into two groups of 18 rats each. A standardised circular 6-mm-diameter wound was made in the dorsal skin region of each rat, and they were euthanised at 1, 6 and 12 h after cutaneous surgery. The blood was collected, and portions of cutaneous tissue and subcutaneous muscle were removed and cryopreserved. Corticosterone levels in the blood were measured by a radioimmunoassay technique; histological sections were submitted to the ELISA technique for analysis of tissue cytokine expression levels. At 6 h after surgery, a significant increase in corticosterone and a significant reduction in the levels of IL-1β and IL-6 in tissues of irradiated wounds were observed when compared to controls (p < 0.05). The levels of TNF-α and IL-10 expression were not significantly different between the groups at different time intervals. Thus, this study strongly suggests a systemic and local biomodulation of low-level laser therapy as indicated by the blood levels of corticosterone and the tissue expression of IL-1β and IL-6, respectively.

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Mast cells (MCs) are mobile cells that contain granules, derived from bone marrow and are widely distributed in tissues actively participating in immune responses. The involvement of these cells has been demonstrated in the inflammation, fibrosis and angiogenesis, in which they act through their secretory products. The purpose of this literature review is to address the involvement of MCs in biological phenomena that comprise the context of tissue repair, such as vasodilation, angiogenesis and fibrosis, with emphasis on the characterization of the profile of these cells in inflammatory lesions mouth. Although few studies contemplate the participation of MCs in oral lesions, some others have shown that these cells are involved in the pathogenesis of periapical lesions, aphthous ulcers, odontogenic cysts, among others. The advancement of knowledge about the mechanism of action of these cells, has stimulated the development of therapies whose chief aim is the regulation of chemical mediators released by mast cells. Therefore, it is hoped that through further investigations, inflammatory disorders of the oral cavity and other conditions that display interstitial MCs,might be better understood, mainly concern to MCs biological behavior.

Grande número das calcificações de tecidos moles na região da cabeça e pescoço podem ser rotineiramente identificadas por meio de exames de imagem, principalmente na radiografia panorâmica, exame amplamente utilizado para análise do complexo maxilomandibular. A avaliação deste exame exige do profissional um vasto conhecimento anatômico das regiões craniofaciais e dos possíveis achados incidentais. Assim, este estudo objetivou revisar a literatura acerca dos achados incidentais comumente encontrados nas radiografias panorâmicas. Foi realizada uma pesquisa bibliográfica de estudos publicados no período de 2016 a 2021 realizada nas bases de dados Pubmed, Lilacs, SciELO e Google Acadêmico utilizando os descritores controlados "radiografia panorâmica", "achados incidentais" e "calcificação vascular". Os principais achados descritos na literatura foram: os ateromas da artéria carótida, flebólitos, sialolitos, tonsilolitos, e as calcificações do complexo estilohióideo. Concluiu-se que os ateromas de carótida e as calcificações do complexo estilohioideo apresentaram uma maior incidência em relação aos demais. A interpretação errônea de um achado incidental ou simplesmente a não observância pode desencadear maiores danos à saúde do paciente já que a saúde oral interfere na saúde sistêmica.