Integrated 131I-SPECT/CT was found to have an additional value over planar imaging in patients with thyroid cancer for correct characterization of equivocal tracer uptake seen on planar imaging as well as for precise localization of malignant lesions in the neck, chest, and skeleton. SPECT/CT optimized the localization of 131I uptake to lymph node metastases versus remnant thyroid tissue, to lung versus mediastinal metastases, and to the skeleton. It also had a further clinical impact on patient management by influencing referral for 131I treatment, tailoring of the administered radioiodine dose, and/or the addition of surgery or external radiation therapy when indicated.

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tive. Compartmentalization could not explain GVHD prevention despite persistence of alloreactive T cells as similarly normal Vβ6+ frequencies were found infiltrating the liver, a GVHD target organ, as were found in the blood, spleen, or lymph nodes. Liver T cells isolated at day +20 from PTCy-treated mice still proliferated robustly (CD8+~35%) in vitro in response to alloantigen although the percentage of proliferating CD8+ T cells and the production of inflammatory cytokines were both reduced compared with mice not treated with PTCy. This reduced functionality of persisting alloreactive T cells may be due in part to the significantly increased frequencies of CD4+CD25+Foxp3+ T cells found in all compartments by day +21. Indeed, PTCy-treated mice were resistant to reinfusion of 40 or 120 × 10 6 splenocytes at +120-150 days, consistent with active suppression being a mechanism underlying the efficacy of PTCy. Overall, our data challenge the existing paradigm of understanding and may guide the rational design of strategies to improve this transplantation platform.