Background: The maternal mortality rate in Indonesia in 2015 according to the Indonesian Demographic and Health Survey (IDHS) is still high at 305 per 100,000 live births. The highest cause of maternal mortality since the last decade is due to bleeding which is 30.3% and postpartum hemorrhage is the most frequent obstetric bleeding. One of the risk factors is anemia in pregnancy. Objectives: This study aims to determine the relationship between hemoglobin levels in mothers in the third trimester of pregnancy with the incidence of postpartum hemorrhage in RSUD Haji Adam Malik Medan. Methods: This study was an analytical research study with a case-control design, using secondary data derived from medical records at RSUP Haji Adam Malik Medan in 2017 – 2018. The study sample was determined using a purposive sampling method of all medical record data that met the study criteria and then analyzed using the chi-square test. Results: From 36 mothers had postpartum hemorrhage (case group) was found that mothers who had experienced postpartum hemorrhage with anemia (Hb < 11 g/dl) in the third trimester of pregnancy as many as 30 people (83,3%) and which had normal Hb (Hb > 11 g/dl) in the third trimester of pregnancy as many as 6 people (16,7%). From the chi-square test had a significant result (p= 0.000; OR = 7.000). Conclusion: There is an association between hemoglobin levels in mothers in the third trimester of pregnancy with the incidence of postpartum hemorrhage. Keywords: hemoglobin levels, postpartum hemorrhage, vaginal delivery   Latar Belakang: Angka Kematian Ibu di Indoensia pada tahun 2015 masih tinggi yaitu sebesar 305 per 100.000 kelahiran hidup. Penyebab kematian ibu tertinggi sejak satu dekade terakhir adalah karena perdarahan yaitu sebesar 30,3% dan perdarahan pascapersalinan adalah perdarahan obstetri yang paling sering terjadi. Salah satu faktor penyebabnya adalah anemia pada ibu hamil. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan kadar hemoglobin pada ibu di trimester III kehamilan dengan kejadian perdarahan pascapersalinan. Metode: Penelitian ini menggunakan desain penelitian case control, menggunakan data sekunder yaitu rekam medik di RSUP Haji Adam Malik Medan tahun 2017 – 2018. Sampel penelitian dipilih dengan metode purposive sampling dari seluruh data rekam medik ibu dengan persalinan spontan pervaginam yang memenuhi kriteria penelitian lalu dianalisis menggunakan uji chi-square. Hasil: Dari 36 ibu dengan persalinan spontan pervaginam yang mengalami perdarahan pascapersalinan (data kasus) ditemukan bahwa ibu dengan persalinan spontan pervaginam yang mengalami perdarahan pascapersalinan dengan kadar Hb < 11 g/dl di trimester III kehamilannya sebanyak 30 orang (83,3%) dan yang dengan kadar Hb > 11 g/dl di trimester III kehamilannya sebanyak 6 orang (16,7%). Uji chi-square menunjukkan hasil yang signifikan (p = 0,000; = 7,000). Kesimpulan: Terdapat hubungan antara kadar hemoglobin pada ibu di trimester III kehamilan dengan kejadian perdarahan pascapersalinan. Kata Kunci: kadar hemoglobin, perdarahan pascapersalinan, persalinan spontan pervaginam

BACKGROUND: Cisplatin (CIS) is an important chemotherapy agent which is widely used for the treatment of many types of solid tumors, which can cause decreased ovarian function. Nigella sativa has been shown to have an anti-inflammatory and anti-oxidant activity that might protect the ovaries from damage due to CIS. AIM: This study aims to understand the benefits of N. sativa protecting the ovaries due to CIS chemotherapy. METHODS: Thirty-two female Rattus norvegicus aged 8 weeks weighing 160–200 g were divided into four groups: Negative control, Positive control, Treatment-1 (CIS 6 mg/KgBW and NS 500 mg/KgBW/day), and Treatment-2 (CIS 6 mg/KgBW and NS 1000 mg/kgBW/day) for 2 weeks. On the 14th day the rats were sacrificed, blood was drawn from the heart, followed by taking ovaries. RESULTS: There was lower mortality and morbidity in CIS + NS 1000 and CIS + NS 500 mg group (p = 0.01 and 0.001). The mean estradiol levels, follicle-stimulating hormone levels, and anti-mullerian hormone levels were not statistically significant among the four groups. The highest number of primary, secondary, tertiary follicles are seen at the CIS + NS 500 mg and CIS + NS 1000 mg groups (p = 0.05). The lowest number of atretic follicles is seen at the CIS + NS 1000 mg group, and the highest number of atretic follicles was in CIS only. CONCLUSION: There is a trend that N. sativa is beneficial in protecting the ovaries from damage caused by CIS.

AIM: To determine the relationship between Chlamydia Trachomatis infections with patency tubal and non-patency tubal occurrence in infertile women. METHODS: This research was an observational analytic research with a cross-sectional study. This research was conducted at Haji Adam Malik General Hospital Medan, Pramita Laboratory Medan and Medical Faculty of Medicine Universitas Sumatera Utara. Laboratory on October 2017 until the number of samples was fulfilled. The samples were women who were referred to Pramita Laboratory Medan for hysterosalpingography procedure in accordance which corresponded to the inclusion criteria by using consecutive sampling technique. RESULTS: From this research, it was found that the most infertile women were aged 31-35 years, with the most infertility type was primary infertility (83,8%) with the longest infertility duration was ≥ 3 years (44%). From all samples who were infertile, 26% among them were positive to chlamydia infection. Eight from twelve people who were infected by Chlamydia Trachomatis experienced non-patency tubal (66.7%) with p-value = 0.001 which showed that there was a relationship between Chlamydia Trachomatis infection with patency tubal and non-patency tubal occurrence in infertile women. CONCLUSION: The proportion of Chlamydia Trachomatis infection in tubal abnormality in this study was 66.7%, whereas Chlamydia Trachomatis infection in the normal tube was 13.2%. It was obtained that there was a significant relationship between Chlamydia Trachomatis infection with tubal abnormality (non-patency tubal) with p-value < 0.005 (p = 0.001).

Background: Stressor is defined as the agent inducing the response of stress. Stress can give a negative impact on cognitives, physiological, and behavioral aspects. One of the effects of stress that can be occur is menstrual cycle disorder. Objectives: To know how is the relationship between stressors and menstrual cycle on medical students in Faculty of Medicine, University of Sumatera Utara. Method: This study used an analytic method with a cross sectional design. The study population was medical students in Faculty of Medicine, University of Sumatera Utara. The data was collected by filling The MSSQ questionnaire and the menstrual data that had been given to respondents if only the inclusion and exclusion criteria was met and used consecutive sampling for the methods. Results: From 80 respondents, the results obtained by Kendall’s Correlation p>0,05 for correlation each stressors with menstrual cycle which means that there is no significant relationship between stressors and menstrual cycle. Conclusion: From this study it can be concluded that there is no significant relationship between stressors and menstrual cycle on medical students in Faculty of Medicine, USU. Keywords: menstrual cycle, stress, stressor   Latar Belakang: Stresor adalah suatu hal yang dapat diidentifikasikan sebagai penyebab timbulnya stres. Stres dapat memberikan dampak negatif dalam aspek kognitif, fisiologi, dan perilaku. Salah satu dampak dari stres yang dapat terjadi adalah gangguan siklus menstruasi. Tujuan: Mengetahui pengaruh faktor stres terhadap siklus menstruasi pada mahasiswi Fakultas Kedokteran Universitas Sumatera Utara. Metode: Metode yang digunakan dalam penelitian ini adalah metode analitik dengan desain cross-sectional. Penelitian dilakukan pada mahasiswi Fakultas Kedokteran Universitas Sumatera Utara. Pengumpulan atau pengambilan data untuk diteliti dilakukan menggunakan kuesioner Medical Student Stressor Questionnaire (MSSQ) dan data siklus menstruasi yang diberikan kepada responden dengan syarat memenuhi kriteria inklusi maupun kriteria eksklusi yang telah ditetapkan serta menggunakan consecutive sampling sebagai metode yang digunakan. Hasil: Dari 80 responden, didapatkan hasil uji Kendall’s Correlation (p>0.05) untuk setiap hubungan faktor stres dengan siklus menstruasi yang berarti tidak ada hubungan yang signifikan antara faktor stres dengan siklus menstruasi. Kesimpulan: Dari penelitian ini disimpulkan bahwa tidak terdapat pengaruh yang signifikan antara faktor stres dengan siklus menstruasi pada mahasiswi Fakultas Kedokteran Universitas Sumatera Utara. Kata Kunci: siklus menstruasi, stres, stresor

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