The water buffalo play a significant role in the economy of livestock industry of Pakistan. The present study was conducted to evaluate the prevalence of reproductive disorders in 928 buffaloes and its economic impact on dairy farms in 2014-15. The data were collected from Landhi Cattle Colony Karachi to analyze the reproductive disorders and mastitis problems in dairy buffaloes. The prevalence of the abortion recorded was 41% which was significantly highest (P<0.01) as compare to others disorders. Whereas, repeat breeding, dystocia, retention of placenta, vaginal prolapse and vaginitis were 32%, 14%, 8%, 5 % and 2% respectively in water buffaloes. Moreover, mastitis cases were 11% in Landhi cattle colony Karachi during study period. The economic losses due to abortion, repeat breeding, dystocia, vaginal prolapse, vaginitis and mastitis were 320, 320, 640, 480, 560, 240 and 640 Pakistan rupees per animal respectively in water buffaloes. In conclusion, findings of the present study indicated that mastitis, abortions and dystocia caused major economic losses to dairy farms at Landhi Cattle Colony Karachi during study period.

Background: Hepatitis C is a diverse illness that causes significant death and morbidity. The hepatitis C virus infects hundreds of millions of individuals globally (HCV). More than 80% of those infected develop chronic infection; the remaining 10–20% recover spontaneously through natural immunity. Acute hepatitis is only icteric in 20% of individuals and is seldom severe. Methods: A pilot study was conducted at INOR hospital Abbottabad. Eleven hepatitis C positive and 10 hepatitis C negative participants were included in the study. Results: A significant difference correlation was found between viral load and SWE quantification for fibrosis stage in Kilo-Pascal, r= 0.904 (p-value=0.000 <a=0.05). HCV positive patients showed a viral load of (Mean±SD) 128,185.8±153,719.1. Conclusion: Although a biopsy is considered to be gold standard for determining the degree of damage caused by chronic viral hepatitis, it is far from perfect. Liver elastography is an intriguing technique that can help physicians make difficult decisions while treating viral hepatitis. This study showed that fibrotic changes of liver are directly proportional to the presence of viral load in blood. The greater the viral load more severe fibrosis will be seen. Age also plays a role in severity of fibrosis, however, more studies on larger population is required to support this statement.