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SUMMARY Surface modified poly(ethy1ene terephthalate) (PET) films with 2-(methacryloyloxy)ethylphosphorylcholine (MPC) and 2-(glucosy1oxy)ethyl methacrylate (GEMA) moieties, PMPC-g-PET and PGEMAg-PET, were prepared by graft copolymerization using an Ar plasma-post polymerization technique. The degrees of polymerization of the grafts PMPC and PGEMA were p,, = 30 and p,, = 40, respectively. The contact angle of the modified PET film decreased from 6' = 68 O (the original PET film) to 6' = 26 O for PMPCg-PET and to 6' = 43 O for PGEMA-g-PET. The modified PET films adsorb less serum proteins than the original PET film. Egg yolk lecithin did not adsorb on PGEMA-g-PET but adsorbed on PMPC-g-PET. PMPC-g-PET showed activity for the inhibition of fibrin formation and no adhesion of mouse fibroblasts (L-929).

A series of copolymer microspheres of 2‐(acryloyloxy)ethylphosphorylcholine (APC) with comonomers (M) such as methyl (MMA), ethyl (EMA), butyl (BMA), hexyl methacrylate (HMA), and styrene (St), i. e. poly(APC‐co‐M) microspheres, were prepared by emulsifier‐free emulsion copolymerization. From the kinetics of the copolymerization, it was found that the initial rate of polymerization of St increases in the presence of small amounts of APC. The diameters of poly‐(APC‐co‐M) microspheres were much smaller than those of the corresponding homopolymer, poly(M). It was confirmed by X‐ray photoelectron spectroscopy measurements that the APC moiety is concentrated on the surface of the particles. A series of poly(APC‐co‐M) microspheres was found to adsorb both bovine serum albumin (Alb) and human serum γ‐globulin (Glo) less that the corresponding poly(M) microspheres as a control.

The photoresponsive copolymer microspheres [poly(MAIP-co-MMA)] were prepared from the emulsifier-free emulsion copolymerization of 2-[2-(methacryloyloxy) ethyldimethylammonio]-ethyl indolinonaphthooxazine phosphate (MAIP) and methyl methacrylate (MMA). From the kinetics of the copolymerization of MAIP and MMA, it was found that the initial rate of polymerization of MMA increased by the addition of a small amount of MAIP. From the X-ray photoelectron spectroscopy (XPS) measurements MAIP moiety was found to be located on the surface of a particle. The introduction of a MAIP moiety into poly(MMA) microspheres results in a decrease in the amount of bovine serum albumin (BSA) adsorbed. A photoresponsive adsorption of BSA on poly(MA1P-co-MMA) microspheres was observed with spirooxazine-merocyanine photoisomerization caused by UV irradiation.

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