Transfersomes are emerging carriersin transdermal applications owing to numerous benefits like ease of application, reduction in dose frequency, In this review, we will describe about the penetration mechanism of transfersomes, method to prepare the formulation and characterization of transferosomal formulation, like thin film hydration, vortexing sonication, modified handshaking, suspension homogenization, centrifugation, and ethanol injection apart from these characterizations include, vesicle size, shape zeta potential, in vitro, and in vivo to find out the optimized formulation charactering the transferosomal preparations chemical, physical and miscellaneous properties to meet the ideal requirements of formulation and achieve the grater bioavailability and to attain good stability. These formulations are gaining good importance as Novel Drug Delivery Systems because of their patient compliance, ultra deformable and flexible nature due to the presence of surfactants and other pharmaceutical excipients like cholesterol, phospholipids in the formulation; hence these are known as first-generation liposomes.

Aim: The main objective of the current research work was to formulate and evaluate Diacerein-loaded transferosomal topical gel to overcome the drawbacks associated with oral administration of Diacerein in Osteo arthritis treatment. Study Design: Transferosomal topical gel Methodology: Transferosomes were developed using different ratios of Phospholipid® 90G as phospholipid and Span-60 as surfactant and cholesterol as fluidity buffer. The selected best formulation of transferosomes was further optimized as a topical gel using different rate controlling polymers such as hydroxylethyl cellulose (HEC), hydroxyl propyl methylcellulose (HPMC) and, carbopol. Transcutol P was used as a penetration enhancer. In vitro diffusion studies of developed formulations were carried out using Franz diffusion cell apparatus. Results: The formulations prepared with Hydroxy ethyl cellulose (TBG1, TBG2, TBG3), HPMC (TBG4, TBG5, TBG6) was shown rapid drug release when compared to formulations prepared with carbopol (TBG7, TBG8, TBG9) are showing controlled drug release.Where the formulation prepared with carbopol with 0.75% concentration has shown acceptable extended drug release for 12 hours with acceptable other physico-chemical properties. Conclusion: It can be concluded that Diacerein-loaded transferosomal gel can be administered topically for the treatment of osteoarthritis with reduced oral side effects.