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Background: It has been observed that several diseases either acute or chronic have a specific symptom that is emesis. Emesis leads to depletion and removal of several salts and biological essentials required in the body. Domperidone is a D2 receptor antagonist, which triggers the chemoreceptor trigger zone (CTZ) and hence used in the management of nausea and vomiting. Objective: The objective of this project was to formulate a buccal patch of domperidone with the use of several polymers with a permeation enhancer. Since the oral bioavailability of domperidone is low due to gastric degradation, hence a buccal patch was prepared to determine its bioavailability. The purpose of this study was to formulate a buccal patch for better bioavailability and observe the effect of permeation enhancer with polymers. Method: The mucoadhesive buccal patch was prepared using the solvent cast method. The characterization studies were done along with the drug content and compatibility studies through FTIR. Results: It was observed that the polymers; sodium carboxy methyl cellulose (SCMC) &polyvinyl alcohol(PVA) without sodium lauryl sulphate (SLS) had low drug release, which was around 68% and 72%, respectively whereas polymers with SLS had markedly increased drug release, which was around 89% and 91%, respectively. Conclusion: In order to obtain the maximum therapeutic efficacy of domperidone, buccal patches are considered much more beneficial than oral dosage form. Permeation enhancer also helps to synergize the effect of polymers which helps in better drug release and ultimately leads to better bioavailability.

Background: Present malignant cancer medicines has the advancement of magnetic nanoparticles as delivery carriers to magnetically accumulate anticancer medication in malignant growth tissue. Aim: In the present investigation, a silica nanoparticles (MSNs) stacked with hydroxyurea were combined and was optimized for dependent and independent variables. Method: In this study, microporous silica nanoparticle stacked with neoplastic medication had been prepared through emulsification followed with solvent evaporation method. Prepared MSNs were optimized for dependent and independent variables. Different formulations were prepared with varying ratio of polymer, lipid and surfactant which affects drug release and kinetics of drug release pattern. The obtained MSNs were identified by FTIR, SEM, drug entrapment, in-vitro drug release, drug release kinetics study, stability testing in order to investigate the nanoparticle characteristics. Results: The percentage drug entrapment of the drug for the formulations F1, F2, F3, was found to be 27.78%, 65.52% and 48.26%. The average particle size for F2 formulation was found to be 520 nm through SEM. The cumulative drug release for the formulations F1, F2, F3 was found to be 64.17%, 71.82% and 32.68%. The formulations were found to be stable which gives controlled drug delivery for 6 hours. Conclusion: From the stability studies data it can be culminated that formulations are most stable when stored at lower temperature or in refrigerator i.e. 5˚C ± 3˚C. It can be concluded that MSN’s loaded with hydroxyurea is a promising approach towards the management of cancer due to its sustained release and less side effects.