Diabetes is a metabolic disorder of the endocrine system which plagues approximately 17 million people nationwide. Each year over 700,000 new cases are diagnosed; 12,000 to 14,000 of which are children, teenagers and young adults, while this life threatening disease can be controlled. Diabetes is often accompanied by serious complications, and still today there is no cure. 1 Foot ulceration and infection in diabetic patients is one of the major causes of morbidity, hospitalization and foot amputation. 2 This complication accounts for approximately 20% of hospital admissions in diabetic patients. 3 Diabetic foot infections include cellulitis, abscess, necrotizing fasciitis, septic arthritis, tendonitis and osteomyelitis. 4 Infections are often polymicrobial, Multi drug resistant and associated with inadequate glycemic control. There is a need for continuous surveillance of resistant bacteria to provide the basis for empirical therapy and reduce the risk of complications. Aims and objectives To isolate and identify the bacterial pathogens associated with Diabetic foot infections. To find out its antibiotic susceptibility pattern.
Aims and Objectives:The aim of this study is to compare the efficacy, safety and cost-effectiveness of topical Whitfield's ointment plus oral fluconazole with topical 1% butenafine in tinea infections of the skin.Materials and Methods:Patients were randomly allocated to the two treatment groups and advised to apply either agent topically twice-a-day for 4 weeks on the lesions and fluconazole (150 mg) was administered once a week for 4 weeks in the study group applying Whitfield's ointment. Patients were followed-up at an interval of 10 days for clinical score and global evaluation response was assessed at baseline and during each follow-up.Results:Out of 120 patients enrolled in the study 103 completed the study. Patients treated with Whitfield's ointment and oral fluconazole reduced mean sign and symptom score from 8.81 ± 0.82 to 0.18 ± 0.59 while butenafine treated patients reduced it from 8.88 ± 0.53 to 0.31 ± 0.67 at the end of the treatment. Nearly, 98% patients were completely cleared of the lesion on the 3rd follow-up with both treatments.Conclusion:Whitfield's ointment with oral fluconazole is as efficacious, safe and cost-effective as compared with 1% butenafine in tinea infections of the skin.
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