Communications to the Editor 1615 our ester with the one prepared by him from digoxigenin. He reported [private communication] that the melting points were identical and that the melting point of a mixture was not depressed. He has also supplied the specific rotation of his ester, [ ]24 ß + 45.6 ± 3°; [a]24D + 38.9 =*= 3°( 1.183% in methanol).The esters of three acids derived from digoxigenin have now been compared with the corresponding esters of known structure.The resultsshow that digoxigenin has a hydroxyl group at C-12, the steric arrangement of which is opposite to that of the corresponding hydroxyl group of desoxycholic acid. A similar steric arrangement of the hydroxyl group at C-12 is present in the alagodesoxycholic acid described by Kishi [Z. physiol. Chem., 238, 210 (1936)].

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CHEMISTRY however, are the results obtained with ether-soluble lac. The values reported in the literature for this portion of lac are generally between 90 and 110, compared with the low value of 70 obtained by the present method. Possibly the ether-soluble portion of lac contains ester linkages highly susceptible to alkali; a structure involving a lactone linkage has been suggested by Bhowmik and Sen (7). The saponification value of the ether-soluble lac is about the same as that mentioned in the literature.

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