No abstract

A systematic pharmacological examination has been made of 55 Jamaican plants, most of which have a local reputation as medicinals. A number of interesting, but no outstanding, activities were observed. The results are tabulated.

No abstract

A full report on the proaporphine alkaloids isolated from Croton linearis Jacq. is presented. Crotonosine is shown to have the structure (I; R = R1 = H), base A is NO-dimethylcrotonosine and is identical with pronuciferine, " homolinearisine " is L-(-)-N-methylcrotonosine, and linearisine is 8,9-(or 11,12)-dihydro-L-(-)-N-methylcrotonosine.COMMUNICATIONS 192 on the structures of proaporphine alkaloids from Croto9z linearis Jacq. reported that crotonosine has the structure ( 11) and linearisine is 8, 9-(or 11, 12)-dihydro-~(-)-Nmethylcrotonosine. We now present a full account of the work leading to these structures.The location of aromatic oxy-substituents was compounds of known structures by unambiguous routes. Hofmann degradation of NOO-trimethylapocrotonosine methiodide, produced by methylation of the aporphine obtained by acid rearrangement of crotonosine, gave the phenanthrene (111) when the product was refluxed with methyl iodide. The melting point of this methiodide was in good agreement with that of the phenanthrene derivative obtained similarly from tuduranine 6 (IV ; R = H, R1 = R2 = Me, R3 = OH). The nuclear magrigorously established by conversionof the alkaloids into 1789.

No abstract