In Ukraine, prevention and control measures of bovine leukosis were regulated by relevant legislation, regulations and instructions developed in the period 1960–1992. Currently, the instruction on prevention and rehabilitation of this disease in cattle is used (approved in 2007). According to it, the identification of infected animals is carried out from 6 months of age by serological (first scheme in AGID or another in ELISA) and genomic (PCR) methods. The infected animals are removed from the herd or slaughtered. In general, because of the diagnostic and preventive measures carried out during the analyzed period (26 years) 10 519 farms were rehabilitated from leukosis (2 346 affected farms remained from previous years). At the same time, more 4 million infected cattle were slaughtered. The majority of affected farms (more than 1 000) were registered in the period between 1994 (2 346 farms) and 2003 (1 247 farms). Since 2014, the number of affected farms has remained mostly below 10 and the number of infected cattle has decreased to 2 000 animals per year. At the same time, the number of rehabilitated farms also decreased (from 1 307 farms in 1998 to 4 farms in 2014). The same trend was registered with the dynamics of the number of animals that were removed from the herd due to leukosis. Thus, in 1995 and 1997 their numbers were 321 178 and 558 649 animals, respectively, and in 2014 it was 1 124. The obtained indicators of intensity and extensiveness of the epizootic process show that the incidence rate was maximal during 1998–2000 and amounted to 3.7–4.3%. The maximum indicators of the coefficient of affection were recorded in 1997–2000 and equal 11.8–15.3%. The rate of foci remained on the level of 90–270 throughout the all analyzed period. During 2008–2019, specialists of the Ukrainian veterinary laboratories investigated more than 47 million samples of cattle blood sera for enzootic bovine leukosis by AGID and ELISA. However, despite the significant diagnostic work, the important factor in the decrease of the number of affected farms and infected animals is the decrease in the total number of cattle in Ukraine (almost 22 million animals in 1994 against 3 million in 2019). Graphic trends of these indicators are comparable and agree with the decrease in the number of cattle in our country by analyzed period. After 2014, the number of affected farms ranged 10–17 per year (mostly in private households). However, the full recovery of cattle in Ukraine from bovine leukosis has not taken place, although our country is closer than ever to this.

The problem of zoonoses remains relevant in the context of reliable prevention of human disease and effective ways to achieve this result, in particular through the impact on susceptible animals by the efforts of veterinary medicine. Anthrax is an acute, particularly dangerous infectious disease of all species of farm, domestic and wild animals, as well as humans, which is caused by Bacillus anthracis microbes. The causative agent of anthrax belongs to the group of aerobic spore-forming bacteria and exists in two main forms: vegetative and spore. The vegetative form in the body of an infected animal can form a "capsule". In Ukraine, according to the provisions of the current "Instruction for the prevention and control of animal anthrax" (2000), the main method of preventing anthrax among animals is regular vaccination of animals susceptible to this disease. The authors conducted a retrospective analysis of the epizootic and epidemiological situation of anthrax in Ukraine for the period 1994–2021 and made a critical assessment of the performance of mandatory measures for specific prevention of susceptible animals. In order to find out the ecological and geographical features of the spread of anthrax, data on outbreaks of the disease in cattle, swine, small ruminants and humans on the territory of Ukraine were analyzed by regions for the time period under investigation. Over the past 28 years in Ukraine, animal anthrax was registered in in all areas except Zhytomyr region. In total, during the analyzed period, 177 affected points and 637 infected animals (cattle, small ruminants, pigs, horses, wild and fur-bearing animals, dogs) were registered (estimated at 3.59 animals per outbreak). Cattle were most often involved in the epizootic process, followed by pigs and small ruminants, while horses and other animal species were least infected. Ecological and geographical analysis showed that the largest number of affected points among animals during the analyzed period was found in Kyiv, Volyn, Kharkiv, Luhansk, Khmelnytskyi, Cherkasy, Odesa, and Vinnytsia regions. A small number of affected points during the analyzed period were found in Zakarpattia, Ternopil, Kherson, Autonomous Republic of Crimea, Poltava, Dnipropetrovsk and Ivano-Frankivsk regions. During the analyzed period, 68 people in 11 regions of Ukraine were infected with anthrax, 15 outbreaks were registered (4.46 people per outbreak). Most cases were reported in Donetsk, Kyiv and Odesa regions. The association between outbreaks of anthrax in animals and cases of anthrax among humans has been established, this dependency was 86.6% (the index of contiguity, which takes into account the number of years with simultaneous registration of animal and human cases, was 0.5). The authors thoroughly proved that it is vaccination among susceptible animals that will finally prevent the incidence of anthrax among people.

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One of the most important livestock industries in the world is poultry breeding, which meets human needs for high-quality protein products (poultry meat, eggs) and is characterized by rapid return on investment. Bacterial infectious diseases of poultry are a major problem for the poultry industry and its strategic future. Given the relevance of bacterial diseases of poultry in the world and in Ukraine in particular, the authors conducted a retrospective analysis of the spread of these diseases in Ukraine for the period 2012–2020 by analyzing and systematizing the results of bacteriological investigations. In order to analyze the spread of bacterial diseases of poultry in terms of regions in Ukraine, we analyzed data on 20 diseases of poultry, namely: hemophilosis, infectious enterotoxemia, yersiniosis, campylobacteriosis, colibacteriosis, coligranulomatosis, klebsiella, listeriosis, mycoplasmosis, neisseriosis, pasteurellosis, pathogenic proteus, pneumococcosis, pseudomonosis, pullorosis, erysipelas septicemia, salmonellosis, staphylococcosis, streptococcosis and tuberculosis. According to the results of research, it is found that bacterial diseases of poultry are significantly common in Ukraine, the average infection of poultry with bacterial diseases for the period from 2012 to 2020 was 0.8%. The leading role in the etiological structure of pathogens of bacterial diseases of poultry was played by colibacillosis – 56.9% of the total number of all positive samples. Also, the dominant bacterial diseases of poultry in Ukraine during the analyzed period are: salmonellosis (13.5%), staphylococcosis (7.8%), pasteurellosis (7.0%), pseudomonosis (6.8%), pullorosis (3.6%) and streptococcus (2.6%). Significantly fewer positive samples were registered in the bacteriological investigations of other diseases: pneumococcosis 0.5%, tuberculosis 0.4%, infectious enterotoxemia 0.3%, pathogenic proteus 0.2%, erysipelas septicemia 0.1%, klebsiellosis 0.1%, listeriosis 0.1%, neisseriosis 0.08%, coligranulomatosis 0.05% and hemophilosis 0.02%. According to the results of bacteriological research of poultry for such diseases as yersiniosis, campylobacteriosis and mycoplasmosis – no positive test was found for the entire analyzed period. According to the results of ecological and geographical analysis, the heterogeneity of the nosological profile of bacterial diseases of poultry in different regions of Ukraine was established.

Aujeszky’s disease, also known as pseudorabies is an acute infectious viral disease in a variety of mammals caused by Suid herpesvirus 1, a member of the subfamily Alphaherpesvirinae and the family Herpesviridae. This virus causes significant economic losses in agriculture of numerous countries. In particular, in pig farming, the main losses are currently associated with restrictions of international trade, as well as the cost of vaccination or slaughter of infected animals. The main reservoirs species of this disease are considered to be wild boars and domestic pigs. So, in this article the authors performed a comparative retrospective analysis of the prevalence of Aujeszky’s disease among these species in Ukraine over 2009–2020 by systematizing and analyzing the epizootic data and results of serological studies. As a result of the conducted research, there is a clear trend that shows the reduction in the number of locations in Ukraine (farms, households, etc.) with domestic pigs affected by Aujeszky’s disease. Thus, in 2009 four such farms were found, and in 2018 – only one. During 2014–2016 and 2019–2020, affected farms and locations were not registered for this disease. In total, 21 such points with infected pigs were registered during the analyzed period. As for wild boars, during the analyzed 12 years, locations with animals affected by Aujeszky’s disease were registered only in 2013 and 2014 (two and one, respectively). It should be noted that all of those with infected wild boars were found in the AR Crimea. For the twelve years, the number of tested sera samples from domestic pigs amounted to 378,678 (7.4% were positive) and from wild boars – 9,052 (19.8% were positive). As a result of comparative geographical analysis of the obtained data on the detection of specific humoral antibodies to the Aujeszky’s disease virus among both species for 12 years in the regions of Ukraine, there is no established clear correlation between the spread of the disease among wild boars and domestic pigs. Thus, the highest seroprevalence rates among wild boars were observed in the northern and northeastern parts of Ukraine, and in domestic pigs, on the contrary, in the southern and central parts of this country. It should be noted, that since 2014 the number of serological tests among both species for carriers of Aujeszky’s disease has significantly decreased.