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BackgroundPhysiological pathways such as bradykinin, renin-angiotensin, neurohormones and nitric oxide have been shown to play an important role in the regulation of cardiovascular function. Genetic variants of these pathways may impact blood pressure and left ventricular (LV) mass in different populations. To evaluate associations of genetic polymorphisms of bradykinin B2 receptor (BDKRB2), alpha-adrenergic receptors (ADRA) and endothelial nitric oxide synthase (eNOS) on the modulation of the blood pressure and the left ventricular mass.MethodsWe enrolled 758 individuals without overt heart disease. Blood pressure was estimated by auscultatory method during the clinical examination. Left ventricular (LV) mass was assessed by echocardiography. Genotypes for ADRA1A rs1048101, ADRA2A rs553668, ADRA2B rs28365031, eNOS rs2070744, eNOS rs1799983, and BDKRB2 rs5810761 polymorphisms were assessed by high-resolution melting analysis.ResultsBDKRB2 polymorphism rs5810761 was associated with blood pressure. Carriers of DD genotype had higher levels of SBP and DBP than carrier of II genotype (p = 0.013 and p = 0.007, respectively). eNOS polymorphism rs1799983 was associated with DBP. Carriers of GT genotype had lower levels of DBP than carriers of GG genotype (p = 0.018). eNOS polymorphism rs2070744 was associated with LV mass. Carriers of TC genotype had higher LV mass than carriers of TT genotype (p = 0.028).ConclusionsIn a cohort of individuals without overt heart disease, the BDKRB2 rs5810761 polymorphism (DD genotype carriers) were associated higher systolic and diastolic blood pressures, and the eNOS rs1799983 polymorphism (T allele carriers) were associated with lower diastolic blood pressure. The eNOS rs2070744 polymorphism (C allele carriers) was associated with higher left ventricular mass. These data suggest that eNOS and bradykinin receptor genetic variants may be potential markers of common cardiovascular phenotypes.

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Esta revisão buscou realizar uma síntese da literatura a respeito dos impactos do uso de tecnologias na qualidade do sono e no processo de aprendizagem dos alunos do ensino médio. Foi realizada uma revisão sistemática de literatura elaborada conforme o protocolo Prisma (Preferred Reporting Items for Systematic reviews and Meta Analyses), na qual utilizamos as bases de dados PubMed, SciELO e Web of Science, foram incluídos estudos publicados do tipo observacional publicados entre os anos de 2014 e 2020, que buscavam avaliar a interferência do uso de equipamentos na qualidade do sono e, consequentemente, no desempenho acadêmico. Não houve limitação de idiomas na busca. Foi encontrado um total de 153 estudos com a busca eletrônica. Destes, apenas 4 atenderam aos critérios de inclusão. Estudos Múltiplos demonstraram que o uso de equipamentos eletrônicos no leito seja para acesso às redes sociais, ou entretenimento por meios dos jogos, tem sido um fator impactante na vida dos adolescentes. Diante disso, constatamos que o uso excessivo de recursos tecnológicos antes de dormir, principalmente no que se refere ao uso de mídias sociais, tem interferido na qualidade do sono, sendo um dos fatores associados a uma redução do desempenho escolar dos estudantes de ensino médio.