Objective: To analyze the influence of Personal Medication Record (PMR) on medication appropriateness. Method: This study used pre-experimental design with one group pretest-posttest design. This study involved 21 parents of epilepsy children, seven neurologist and four pharmacy personnel.The data was analyzed by using Mc Nemar test. Result: Based on the Mc Nemar test, there is no statistically significant difference on the medication appropriateness before and after the use of PMR (p>0,005). Nevertheless, neurologist and pharmacy personnel can do medication reconciliation through PMR as a comprehensive documentation medium. PMR has also a clinically positive impact on improving the medication appropriateness for each patient. Conclusion: The use of Personal Medication Record (PMR) does not give any influence towards medication appropriateness.