AimsThe secreted form of the α-Klotho gene (S-Klotho), which is considered a powerful biomarker of longevity, makes it an attractive target as an anti-ageing therapy against functional decline, sarcopenic obesity, metabolic and cardiovascular diseases, osteoporosis, and neurodegenerative disorders. The S-Klotho plasma levels could be related to physical exercise inasmuch physical exercise is involved in physiological pathways that regulate the S-Klotho plasma levels. FIT-AGEING will determine the effect of different training modalities on the S-Klotho plasma levels (primary outcome) in sedentary healthy adults. FIT-AGEING will also investigate the physiological consequences of activating the klotho gene (secondary outcomes).MethodsFIT-AGEING will recruit 80 sedentary, healthy adults (50% women) aged 45–65 years old. Eligible participants will be randomly assigned to a non-exercise group, i.e. the control group, (n = 20), a physical activity recommendation from World Health Organization group (n = 20), a high intensity interval training group (n = 20), and a whole-body electromyostimulation group (n = 20). The laboratory measurements will be taken at the baseline and 12 weeks later including the S-Klotho plasma levels, physical fitness (cardiorespiratory fitness, muscular strength), body composition, basal metabolic rate, heart rate variability, maximal fat oxidation, health blood biomarkers, free-living physical activity, sleep habits, reaction time, cognitive variables, and health-related questionnaires. We will also obtain dietary habits data and cardiovascular disease risk factors.

The aim of this study was to study the effects of a 6-session (one per week) WB-EMS training intervention on maximum oxygen uptake, aerobic and gas exchange thresholds, running economy, and muscular power in male recreational runners. Twelve men were randomized into WB-EMS intervention (n = 6; 27.0 ± 7.5 years; 70.1 ± 11.1 kg; 1.75 ± 0.5 m) or control (n = 6; 27.0 ± 6.1 years; 73.6 ± 3.4 kg; 1.77 ± 0.3 m). The WB-EMS group reduced the running training frequency to one per week and followed one WB-EMS training session per week during 6 weeks. Participants in the control group maintained their usual running endurance training. Each participant completed four assessments: physiological parameters [(i) VO2max, aerobic and gas exchange threshold values, and (ii) running economy at two intensities], muscular power (vertical jump), and anthropometric parameters both at baseline and after the intervention. Participants in the WB-EMS group improved VO2max, aerobic and gas exchange threshold values, running economy, and vertical jump (p < 0.05) compared to the control group. There, WB-EMS seems to be an effective training methodology leading to improvements in performance during endurance training volume reduction in male recreational runners.

The popularity of whole-body electromyostimulation is growing during the last years, but there is a shortage of studies that evaluate its effects on physical fitness and sport performance. In this study, we compared the effects of a periodized and functional whole-body-electromyostimulation training on maximum oxygen uptake (VO2max), ventilatory thresholds (VT1 and VT2), running economy (RE), and lower-body muscle strength in runners, vs. a traditional whole-body-electromyostimulation training. A total of 12 male recreational runners, who had been running 2–3 times per week (90–180 min/week) for at least the previous year and had no previous experience on WB-EMS training, were enrolled in the current study. They were randomly assigned to a periodized and functional whole-body-electromyostimulation training group (PFG) (n = 6; 27.0 ± 7.5 years; 70.1 ± 11.1 kg; 1.75 ± 0.05 m) whose training program involved several specific exercises for runners, or a traditional whole-body-electromyostimulation training group (TG) (n = 6; 25.8 ± 7.4 years; 73.8 ± 9.8 kg; 1.73 ± 0.07 m), whose sessions were characterized by circuit training with 10 dynamic and general exercises without external load. The training programs consisted of one whole-body electromyostimulation session and one 20-min running session per week, during 6 weeks. The PFG followed an undulating periodization model and a selection of functional exercises, whereas the TG followed a traditional session structure used in previous studies. Both groups were instructed to stop their habitual running training program. VO2max, VT1, VT2, RE, and lower body muscle strength (vertical jump) were measured before and after the intervention. The PFG obtained significantly higher improvements when compared with the TG in terms of VO2max (2.75 ± 0.89 vs. 1.03 ± 1.01 ml/kg/min, P = 0.011), VT2 (2.95 ± 1.45 vs. 0.35 ± 0.85 ml/kg/min, P = 0.005), VO2max percentage at VT2 (5.13 ± 2.41 vs. 0.63 ± 1.61%), RE at VT1 (−7.70 ± 2.86 vs. −3.50 ± 2.16 ml/kg/km, P = 0.048), RE at 90% of VT2 (−15.38 ± 4.73 vs. −3.38 ± 4.11 ml/kg/km, P = 0.005), and vertical jump in Abalakov modality (2.95 ± 0.94 vs. 0.52 ± 1.49 cm, P = 0.008). Therefore, we conclude that running performance improvements were better after a 6-week program following an undulating periodization and consisting on functional exercises when compared with a 6-week traditional WB-EMS program.

La electroestimulación de cuerpo completo (WB-EMS) es una metodología de entrenamiento novedosa cuyo efecto sobre la composición corporal no ha sido estudiado en profundidad en población joven y físicamente activa. El objetivo del estudio fue determinar el efecto de dos programas de entrenamiento con WB-EMS sobre la composición corporal, medida a través del Índice de Masa Corporal (IMC), masa grasa (MG), masa libre de grasa (MLG) y densidad mineral ósea (DMO) en corredores recreacionales entrenados durante un periodo de cese parcial en su entrenamiento convencional y comparar el efecto de dos programas de entrenamiento con WB-EMS, funcional y periodizado para corredores vs no funcional y no periodizado sobre el IMC, MG, MLG y DMO. Participaron un total de 18 corredores recreacionales sanos (27,1 años; IMC= 23,2 Kg/m2). Los sujetos se distribuyeron al azar en tres grupos: (i) entrenamiento WB-EMS funcional y periodizado para corredores, (ii) entrenamiento WB-EMS no funcional y no periodizado, y (iii) grupo control. La composición corporal se analizó por antropometría y bioimpedanciometría eléctrica determinándose el IMC, MG, MLG y DMO. Los resultados del estudio ponen de manifiesto que el entrenamiento con WB-EMS (independientemente de la modalidad) produjo descensos significativos en IMC y MG (P<0,05), experimentándose una tendencia en términos de mejora de MLG sólo en el grupo WB-EMS funcional (P=0,053) al comparar con el grupo control, no observándose cambios en DMO. Por lo tanto, podemos concluir que un programa de entrenamiento WB-EMS produce mejoras significativas en la composición corporal en corredores recreacionales entrenados, específicamente en IMC y MG, y clínicamente relevantes en MLG únicamente en el grupo WB-EMS funcional.Palabras clave: WB-EMS, corredores, masa grasa corporal, masa libre de grasa, IMC. ResumenCorrespondencia/correspondence: Francisco José Amaro-Gahete Departamento de fisiología. Universidad de Granada. Spain Email: amarof@ugr.es Whole-Body-Electromyostimulation (WB-EMS) has become a new training tendency but its effect on body composition has not been thoroughly studied in young trained population. The principal aim of this study was to determine the effect of two types of WB-EMS training modalities (specific, functional and periodized for runners vs non-specific, non-functional and non-periodized on body composition variables, as body mass index (BMI) fat mass (FM), fat free mass (FFM) and bone mineral density (BMD) in recreational trained runners during endurance training cessation and to compare the effects of two WB-EMS training modalities, functional vs non-functional on BMI, FM, FFM and BMI. 18 healthy recreational runners (27.1 years; BMI= 23.2 Kg/m2) were randomized in three groups: (i) functional WB-EMS, (ii) non-functional WB-EMS and (iii) control group. Body composition parameters were assessed by anthropometry and bio-impedance and the variables measured were BMI, FM, FFM and BMD. Both WB-EMS modalities produced a significant decreases in BMI and FM (p<0.05) and it was...

The present study investigates the effect of an acute intake of caffeine on the diurnal variation of neuromuscular performance in resistance-trained women. A total of 15 resistance-trained women participated in the current triple-blind, placebo-controlled, crossover experimental study. We assessed neuromuscular performance (i.e. ballistic (countermovement jump [CMJ] height and bench press throw [BPT] peak velocity), maximal strength (squat and bench press [BP] onerepetition maximum [1RM]), and strength-endurance [average velocity of the set during squat and number of repetitions-to-failure in BP]) four times at within 7 days. The participants ingested an acute dose of caffeine (3 mg/kg) or a placebo at 9-11 am and/or 17-19 pm. CMJ height (P = .016) and BP peak velocity (P = .012) were higher in the afternoon than in the morning. Compared to placebo, caffeine intake increased CMJ height by 3.1% in the morning and 1.6% in the afternoon (P = .035), but it had no effect on BPT peak velocity (P = .381). Maximal strength and strength-endurance performances were not affected by the time-of-day or caffeine intake (all P > .3). No significant interaction (time-of-day x substance) was observed in any of the above-mentioned outcomes (all P > .1). In conclusion, an acute dose of caffeine in the morning was effective to restore CMJ performance to levels found in the afternoon, while this effect was not observed neither in BPTpeak velocity nor in lower-and upper-body maximal strength and strength-endurance performance. Moreover, lower-and upper-body ballistic performance were greater in the afternoon than in the morning in resistance-trained women, while the acute intake of caffeine was only effective to increase CMJ height. Highlights. Ballistic performance is probably higher in the afternoon than in the morning in resistancetrained women. . An acute intake of caffeine is effective to increase countermovement jump performance.. The ingestion of an acute dose of caffeine in the morning restored countermovement jump performance to levels found in the afternoon.