This paper describes an investigation into the viability of mental models used by novice programmers at the end of a first year Java programming course. The qualitative findings identify the range of mental models of value and reference assignment held by the participants. The quantitative analysis reveals that approximately one third of students held non-viable mental models of value assignment and only 17% of students held a viable mental model of reference assignment. Further, in terms of a comparison between the participants' mental models and their performance in incourse assessments and final examination, it was found that students with viable mental models performed significantly better than those with non-viable models. These findings are used to propose a more "constructivist" approach to teaching programming based on the integration of "cognitive conflict" and program visualisation.

The potential of tabletops to enable simultaneous interaction and face-to-face collaboration can provide novel learning opportunities. Despite significant research in the area of collaborative learning around tabletops, little attention has been paid to the integration of multi-touch surfaces into classroom layouts and how to employ this technology to facilitate teacher-learner dialogue and teacher-led activities across multi-touch surfaces. While most existing techniques focus on the collaboration between learners, this work aims to gain a better understanding of practical challenges that need to be considered when integrating multi-touch surfaces into classrooms. It presents a multi-touch interaction technique, called TablePortal, which enables teachers to manage and monitor collaborative learning on students' tables. Early observations of using the proposed technique within a novel classroom consisting of networked multi-touch surfaces are discussed. The aim was to explore the extent to which our design choices facilitate teacher-learner dialogue and assist the management of classroom activity.

The teaching of introductory computer programming seems far from successful, with many first year students performing more poorly than expected. One possible reason for this is that novices hold 'non-viable' mental models (internal explanations of how something works) of key programming concepts which then cause misconceptions and difficulties. An initial study investigated the apparent viability of novices' models of fundamental programming concepts, focusing on value and reference assignment. This revealed that many students appeared to hold 'non-viable' mental models of these key concepts and that those students who appeared to hold viable mental models performed significantly better in programming tasks than those with non-viable models. To address this, a teaching model integrating cognitive conflict and program visualisation is proposed. A series of studies found that this teaching model is potentially effective in enhancing engagement with learning materials and may therefore help novice programmers develop a better understanding of key concepts

Recent research has found that many novice programmers often hold non-viable mental models of basic programming concepts such as assignment and object reference, which can limit their potential to develop programming skills. This paper proposes a constructivist-based teaching model that integrates cognitive conflict and program visualisation with the aim of supporting novice programmers in the formulation of appropriate mental models. The results of an initial empirical study produced three findings of note. Firstly, a teaching model based on either visualisation alone or cognitive conflict integrated with visualisation can help students develop viable models of value assignment. Secondly, there was evidence to suggest that cognitive conflict integrated with visualisation outperformed visualisation alone in helping students develop viable models of the more challenging concept of object reference assignment. And thirdly, there was evidence of an improvement in students' understanding of value and object reference assignment using the teaching model based on visualisation and cognitive conflict

Rheumatoid arthritis (RA) is a chronic inflammatory disease, which is associated with symptoms, including synovial membrane inflammatory pain, joint synovitis and stiffness. However, there are no effective methods available to cure this disease. In the present study, rapamycin was used to modulate immunity in RA. To limit the cytotoxicity of rapamycin, rapamycin was loaded into well-characterized biocompatible nanoparticles. In vitro, rapamycin particles downregulated the activation of dendritic cell surface markers, including CD80+ and CD40+, upon interacting with macrophages. The rapamycin particles reduced the secretion of inflammatory cytokines, including interleukin (IL)-6, tumor necrosis factor (TNF) and IL-1β, which are characteristic of RA. In vivo, the rapamycin particles decreased the symptoms of RA in mice, and the production of inflammatory cytokines was associated with the occurrence of RA. The present study partially revealed the interactions between rapamycin and two types of immune cell in RA disease, and may potentially offer a solution to improve the treatment of RA.