Unique two-dimensional water channels formed by stacked graphene oxide (GO) sheets that are "nonleachable" and nonswellable can show great potential for water remediation. The interlayer spacing controls the solute or ion sieving and plays a crucial role in water transport in GO-based membranes. Herein, the sub-nano-channels adjacent to the sheets are altered by either ionic or covalent cross-linking using magnesium hydroxide (Mg(OH) 2 ) and graphene oxide quantum dots (GQDs) (named GOM and G-GQD), respectively. In aqueous solution, these cross-linkers prevent the GO sheets from swelling and precisely control the interlayer spacing required for water permeation. In addition, these narrowed GO sheets facilitate significant improvement in salt rejection of a divalent ion by forward osmosis and selective dye rejection and are resistive toward biofouling and bacterial growth. The cross-linked GO membranes are robust enough to withstand strong cross-flow velocity and aided in unimpeded water transport through the nanochannels. Among the membranes, the G-GQD membranes (G-GQD) show better antifouling characteristics, dye separation performance over 95− 97% for various dyes, divalent ion rejection by 97%, and no cytotoxicity against HaCaT cells as compared with other GO membranes. Our findings on interlocking the domains of nanoslits of the GO structure by small ecofriendly molecules portray these materials as potential candidates for water separation applications.
Polymeric architectures with controlled and well-defined structural features are required to render a sustainable antibacterial surface - a key requirement in the design of polymeric membranes for water purification. Herein, surface selective crosslinking of copper oxide-polyphosphoester (CuO-PPE) hybrid nanogels on to polyvinylidene fluoride-styrene maleic anhydride (PVDF/SMA) ultrafiltration membranes was developed. The hybrid nanogels, composed of PPE and CuO, with inherent antifouling and antibacterial properties, were crosslinked using a macroinitiator (polyethylene glycol, PEG) and subsequently grafted on to PVDF/SMA by alkyne-anhydride reaction. Partially hydrolysed SMA solubilizes membrane proteins and the phosphatase/phospholipase triggers the cleavage of PPE segments resulting in controlled release of Cu ions. This unique strategy renders the membrane surface antibacterial through sustained and controlled release of Cu ions thereby generating intracellular reactive oxygen species (ROS). In addition, the enhanced antibiofouling performance of these membranes is facilitated by the presence of the hydrophilic macroinitiator (PEG and PPE). The modified membranes designed in this study are durable and possess long-term stability due to strong covalent interaction between CuO-PPE and the PVDF/SMA membrane. Studies on the flux, porosity and protein adsorption of the membranes were performed. An enhanced flux recovery ratio was observed for the modified membrane due to the pendant PPE groups (from CuO-PPE) which prohibit irreversible protein adsorption on the PVDF surface. The cytotoxicity of CuO-PPE is greatly reduced because of an effective coverage of CuO by biocompatible PPEs. This study opens up new avenues of fabricating "smart" inorganic nanoparticles that can be confined in a soft hybrid polymeric gel network with controlled release of Cu ions thereby precluding ubiquitous bacterial treatment in water filtration systems.
The array highly efficiently promotes cardiomyogenic commitment of stem cells via integrin-mediated signalling compared to the smooth surface and is a potential platform for ex vivo differentiation of stem cells for cell therapy in cardiac tissue repair and regeneration.
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