No abstract

No abstract

No abstract

Background Renin Angiotensin Aldosteron System plays major role in hypertension pathophysiology. Has been proposed that half of individuals with essential hypertension are considered insulin resistant. Angiotensin Converting Enzyme gene polymorphism taking the control of ACE level in human plasma. There might be a correlation between ACE gene polymorphism and plasma glucose level. Objective This study sought to investigate ACE gene polymorphism insertion/deletion in hypertensive patients and its correlation with plasma glucose level. Method A total of 100 hypertensive patients at Saiful Anwar cardiovascular outpatients clinic who received ACEi at least 8 weeks were included. ACE genotype were determined by polymerase chain reaction method, and plasma glucose level was measured by enzymatic colorimetric assay method. Result The II, ID, and DD genotype were observed in 48%, 29% and 23% of participant, respectively. The fasting and 2 hours post prandial plasma glucose were significantly higher in DD genotype patients. The insertion/ deletion polymorphisms were not related significantly to age, sex, cough, and controlled blood pressure of those patients. Conclusion This study showed that 23% of hypertensive patients had DD genotype with higher plasma glucose level as compare to those of II and ID genotype.(J Kardiol Indones. 2016;37:13-8) Latar Belakang : Sistem Renin Angiotensin Aldosteron berperan penting dalam hipertensi. Telah diperkirakan bahwa separuh dari pasien dengan hipertensi primer memiliki resistensi terhadap insulin. Polimorfisme gen Angiotensin Converting Enzyme (ACE) dianggap bertanggung jawab terhadap kadar ACE dalam plasma. Diprediksi terdapat hubungan antara polimorfisme gen ACE dengan tingginya kadar gula pada pasien hipertensi. Tujuan : Mempelajari hubungan antara polimorfisme gen ACE dengan kadar gula darah pada pasien hipertensi. Metode : Sebanyak 100 pasien hipertensi dari Poli Jantung Rumah Sakit dr.Saiful Anwar Malang yang menerima terapi dengan penghambat ACE selama 8 minggu diambil darahnya untuk dianalisis polimorfisme gen ACE serta dilakukan pengukuran kadar gula darah. Hasil : Genotip II, ID, dan DD ditemukan sebesar 48%, 29% and 23% masing-masing Kadar gula darah puasa dan 2 jam sesudah makan lebih tinggi signifikan pada kelompok pasien dengan genotip DD. Sedangkan terhadap usia, jenis kelamin, dan terkontrolnya tekanan darah tidak ditemukan hubungan dengan polimorfisme gen ACE. Kesimpulan: 23% pasien hipertensi dengan genotip DD memiliki gula darah yang lebih tinggi dibanding genotip II dan ID.(J Kardiol Indones. 2016;37:13-8) Kata kunci : gen angiotensin converting enzyme gene, insersi/delesi, kadar gula darah

Background: Ganodermalucidum was developed as a comprehensive approach for cardiovascular diseases. Efforts to develop polysaccharide peptide(Ganodermalucidum) as antioxidant and antiinflammation in previous studies had proved its ability to significantly reduce the level of MDA, hs-CRP, H 2 O 2 , total cholesterol, and foam cell and also increase the level of HDL in Rattusnovergicuswistar strain rats which was givenhigh fat diet. Furthermore, additional study has to be done to understandthe toxicity effect of subchronic administration of polysaccharide peptide (Ganodermalucidum).Objective: To understand the safety profile of renal function in the use of polysaccharide peptide (Ganodermalucidum) through subchronic toxicity test in animals.Methods: Subchronic toxicity test in RattusnovergicusWistar strain rats, with 6 rats/sex/group was given pure solution (freeze dried) of Ganodermalucidum with the dose of 0, 300, 600, 1200 mg/kgBB using feeding tubeonce a day for 90 days.Result: Until the 90 th day after administration ofpure extract of Ganodermalucidum (freeze dried) with the dose of 300,600,1200 mg/kgBB in male and female rats, there was no toxic symptoms and did not affect the target organ kidney. The gross pathology and histopathology examination of the kidney showed no morfological and histopathology abnormality finding. Conclusion:There was no toxicity effect to the target organ kidney in subchronic oral administration of polysaccharide peptide(Ganodermalucidum) up to the dose of 1200 mg/kgBB/day. Background:High prevalence of target organ damage in hypertensive patients might be preventable by early proper adequate treatment. Early recognation of blood pressure pattern using ambulatory blood pressure monitoring and serum renin level may correlate with development of target organ damage. Objective:The study aimed to examine ambulatory blood pressure pattern and left ventricular hypertrophy (LVH) as well as and serum renin level in hypertensive patients.Methods: A total of eighteen hypertensive patients were randomly selected from hypertensive patients in cardiology outpatient clinic of Saiful Anwar hospital Malang. Patients with known secondary hypertension, active bleeding, cirrhosis, pregnancy, on corticosteroid and/ or estrogen therapy were excluded. Twenty-four hours ambulatory blood pressure (ABP) monitoring was measured to determine blood pressure pattern. LVH measured by Trans Thoracic Echocardiography and serum renin level measured by ELISA. Results: Uncontrolled blood pressure observed in 55.6% of patients. Non-dipping pattern observed in 94.4%. Concentric hypertrophy/concentric remodelling (LVH) and normal was observed in 66.7%, and 33.3% respectevelly. No significant association observed between dipping patern and LVH (p = 0.70). There was no difference of serum renin level between dipping and non-dipping hypertensive patients (31.50 vs 36.99 ± 9.93, P = 0.598). No difference of serum renin level in hypertensive patient with and without LVH (39.25 ± 25 vs 35.40 ± 11.57, P = 0.314). Conclusion:N...