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The purpose of our research was to study the association of the PNPLA3 SNP rs738409 (C>G) with type 2 diabetes (T2D) in the Yakuts. The frequency distribution of alleles and genotypes of the PNPLA3 SNP rs738409 was in accordance with HWE. There were no statistically significant differences in the distribution of alleles and genotypes of the PNPLA3 SNP rs738409 between T2D patients and non-T2D patients (P>0.05); the G allele and homozygous GG genotype prevailed in both groups. In T2D patients, a high frequency of the G allele (74.1%) was found, with a predominance of the GG genotype (58.5%). We also found that the mutant allele frequency is higher than in the studied populations of the world. Further studies with larger sample size are required to achieve sufficient statistical power to detect the association of the PNPLA3 SNP rs738409 with the development of T2D in Yakut patients. (International Journal of Biomedicine. 2018;8(3):201-205.)

The aim of the study was to present somatotypological characteristics of women (age 36-74 years) of Yakut ethnicity with type 2 diabetes (T2D). Materials and Methods: The examined women with diagnosed T2D belonged to the age group of 36-55 years (n=24) and the group of 56-74 years (n=64). The comparison group (n=826) consisted of women of the same age periods who were not suffering from T2D. All examined women were born and permanently resided in Yakutia. Anthropometric examination, bioelectrical impedance analysis and the somatotypological method of examination were performed. Results: The results indicate a significant predominance of overweight and obesity in Yakut women with T2D. Somatotypological analysis by the Rees-Eysenck body index, the Tanner scale and the Heath-Carter method also revealed a number of features. In the group of women with T2D, we found that individuals with andromorphic body type (according to sexual dimorphism index) and mesoectomorphic body type (according to the Heath-Carter index) were prevalent and that the proportion of individuals with asthenic somatotype, according to the Rees-Eysenck body index, was smaller. Identification of marked body types in the female population of Yakutia can serve as an additional prognostic criterion in a complex of studies aimed at the early detection of T2D.