We offered a strategy for constructing a polyphenol-amine coating with TA and lysine for efficient heparin immobilization. The coated substrates showed good anticoagulant properties and biocompatibility.

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The fact that multidrug resistance (MDR) could induce medical device‐related infections, along with the invalidation of traditional antibiotics has become an intractable global medical issue. Therefore, there is a pressing need for innovative strategies of antibacterial functionalization of medical devices. For this purpose, a multimodal antibacterial coating that combines photothermal and photodynamic therapies (PTT/PDT) is developed here based on novel heavy atom‐free photosensitizer compound, BDP‐6 (a kind of boron‐dipyrromethene). The photothermal conversion efficiency of BDP‐6 is of 55.9%, which could improve biocompatibility during PTT/PDT process by reducing the exciting light power density. Furthermore, BDP‐6, together with oxidized hyaluronic acid, is crosslinked with a natural polymer, gelatin, to fabricate a uniform coating (denoted as polyurethane (PU)‐GHB) on the surface of polyurethane. PU‐GHB has excellent synergistic in vitro PTT/PDT antibacterial performance against both susceptible bacteria and MDR bacteria. The antibacterial mechanisms are revealed as that hyperthermia could reduce the bacterial activity and enhance the permeability of inner membrane to reactive oxygen species by disturbing cell membrane. Meanwhile, in an infected abdominal wall hernia model, the notable anti‐infection performance, good in vivo compatibility, and photoacoustic imaging property of PU‐GHB are verified. A promising strategy of developing multifunctional antibacterial coatings on implanted medical devices is provided here.

Biomedical device‐associated infection (BAI) is a common symptom in hospitals. To solve this problem, the biomedical device needs fast, efficient, and safe antibacterial methods to prevent infection. Herein, a strategy for surface antibacterial functionalization is proposed, using mild photothermal effect and quaternary ammonium salt to common sterilize. Au nanorods (NRs) and quaternized N,N′‐dimethylethylenediamine (QDED) (quaternary ammonium salt) are modified on the surface of polyurethane (PU) to fabricate PU‐Au‐QDED. First of all, stable and recyclable mild photothermal radiation is achieved by low‐power near‐infrared (NIR) light irradiation, and then in a shorter time of NIR irradiation, mild photothermal effect promotes the disturbance of the alkyl chain of quaternary ammonium salt to destroy the bacterial membrane, together with quaternary ammonium salt QDED that has fast and efficient antibacterial property, especially against multidrug‐resistant bacteria. Meanwhile, mild photothermal effects, together with quaternary ammonium salt QDED, have good biocompatibility. Among all of the samples, PU‐Au‐Q5 demonstrates fast, efficient, and safe antibacterial performances. At the same time, the antibacterial mechanisms are further studied. Finally, the in vivo antibacterial properties are verified by the subcutaneous implantation animal model. The present work provides a facile and promising approach to develop high‐performance antibacterial biomedical devices.

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