Background: People with HIV/AIDS require treatment with ARV to reduce the amount of HIV virus in the body it does not enter the AIDS stage, while people with AIDS require ARV treatment to prevent opportunistic infections with various complications. Aim: Determine antiretroviral medication adherence of PLWHA, get information on the facts that influence PLWHA in using ARVs, analyze factors that influence PLWHA in using ARV, and get information about management treatment antiretroviral of PLWHA. Method: a systematic review. Research information was obtained by utilizing the Google Sholar facility and index of journal publications. Result: Factors related to antiretroviral medication adherence to PLWHA include family support, level of knowledge, peer group support, side effects of medicine, motivation, behavioral skills, psychology of PLWHA patients, boredom, stigma, health care facilities, therapy guidelines, characteristics of comorbidities, perception, gender, health insurance, self-efficacy, social isolation, age, education level, income, duration of treatment with ARV, support from health workers, spiritual motivation, and utilization of health services for the last three years. Conclusion: Adherence and family support are important roles in healing PLWHA. PLWHA must obedient to treatment with antiretrovirals. Family support is an important role in healing PLWHA. They suggested to the families of PLWHA to give motivation and comply with the advice of health workers.