The paper discusses the prospects for the use of probiotic drugs as an alternative to growth-stimulating antibiotics, which, according to current scientific research, have shown themselves as drugs that allow getting livestock and poultry products that are safe in all respects. The results of the conducted studies allow drawing conclusions about the biological safety of probiotics in terms of its residual amount in the tissues of slaughter animals, which excludes a negative effect on the consumer's body.

The territory of the Pavlodar region is a natural focus with a high intensity of the spread of opisthorchiasis invasion among people. One of the important preventive measures in the foci of opisthorchiasis is the elimination of helminths in the body of the main owners, which leads not only to the rupture of the biological chains of helminth development, but also to the protection of the environment from invasive pollution. Opisthorchiasis is widespread in the Pavlodar region, the extensiveness of invasion among carnivores is 5.7%. Cases of the incidence of cats were detected in five out of 10 districts (Aksu, Aktogay, Pavlodar, Shcherbaktinsky, Maysky), dogs -in two districts (Terenkol, Irtysh). Opisthorchiasis was not revealed in the study of the pig population. Cats and dogs, especially in coastal rural settlements of the region, support the existence of opisthorchiasis foci and contribute to their stabilization. The main source of the release of opisthorchis eggs into the external environment are cats, their infection rate is 2 times higher than that of dogs. In the Pavlodar region, opisthorchiasis of animals is caused by the O. felineus pathogen or cat fluke.

Immunocompetent cells in the blood, colostrum (milk) of cows and in the blood of newborn calves obtained from these animals give grounds to assert that newborn calves acquire cellular immune protection due to the intake of colostrum. With the colostrum of cows, not only nonspecific, but also specific immunocompetent cells enter the newborn’s body. The creation of colostral immunity is determined by the presence of a sufficient number of protective factors in colostrum and increased permeability of the intestinal histohematogenous barrier, which is capable of passing large immunoglobulin bodies and lymphocytes unchanged in the first 24-36 hours of life. A large number of specific immunocompetent cells found in colostrum is directly related to their increased content in the blood of these animals. The strength of the immune response depends on the preservation of immunological memory cells in the blood of revaccinated animals, some of which are represented in the pool of brucellin-reactive T-lymphocytes.

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