No abstract

This PET study is the first in which is described the effect of cervical SCS on glucose metabolism in brain tumors and supports previous study data indicating a modification of locoregional blood flow and oxygenation by cervical SCS. These results open up new approaches to modifying the effect of radiochemotherapy in the treatment of malignant brain tumors.

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To develop a practical means of auditing the procedures and to optimize the administered radionuclide activity, patient surface radiation doses following the administration of 18FDG for PET imaging have been measured at breast and gonad locations at two PET facilities. Patient dosimetry was performed using LiF TLD-100 chips placed near the breasts and gonads for 2 h following tracer injection. Standard uptake values from the image-reconstruction algorithms of one PET camera were investigated in regions of interest in tomograms of the myocardium and liver with the aim of validating dosimetry at breasts. Mean doses measured on the patient's skin ranged between 3.3 and 6.1 microGy MBq(-1) at the gonads and between 3.9 and 6.4 microGy MBq(-1) at the breasts, noticeably lower than the calculations reported in the literature. These values show good concordance with the injected activities, although they are not proportional. The proportion of injected activity actually contributing to image production seems to decrease gradually as the injected activity increases. Conversely, for a given injected activity, breast and gonadal doses were found to be lower than the values expected from the numerical calculations reported in the literature, showing increasing discrepancies when the injected activity increased. Doses measured at the right breast were consistently higher than for the left, which is indicative of greater radiotracer absorption by the liver compared to the average absorption in the body.