Non-acylated Quaternary Ammonium Salts from Aliphatic Amines 753 XIII did not readily add bromine. The methyl alcoholic filtrate of this experiment yielded 18.5% of IV when diluted with water, melting point and mixed melting point with a sample of this compound described in another experiment, 57°. This product also turned pink upon exposure to light.Acknowledgment.-We wish to express our appreciation to Mrs. M. S. Sherman for carrying out the recorded microanalyses. Summary The molecular rearrangement of fluorylidene dimethyl sulfide to fluorene-1 -dimethyl sulfide was effected in an alkaline medium. By graded oxidation the rearrangement product was converted into fluorene-1 -dimethyl sulfone, fluorenone-1-dimethyl sulfone and fluorenone-1-carboxylic acid. The above-named acid and its ethyl ester were characterized by comparison with authentic specimens. The -SCH3 group of fluorene-1 -dimethy 1 sulfide was substituted by -OCH3, -Br, -OH and -H. Fluorene-1methyl bromide in an alcoholic solution of sodium methylate yielded sym.-difluorene-1,1 '-ethylene and fluorene-1 -dimethyl oxide.

The activity of these compounds against E.typhosa is considerably below that already reported for cetyltriethylammonium bromide and cetyltri-M-butylammonium bromide. Summary N -Carbamylmethyl, N-carbethoxymethyl and Nß-acetoxyethyl derivatives of several quaternary ammonium compounds containing one Ncetyl or N-lauryl group and three low molecular weight N-alkyl radicals were prepared. The germicidal activity of these compounds was studied, and in some, cases the effect on the activity of different anions was tested.In the N-lauryl group of compounds the germicidal activity was improved by the substitution of a carbethoxymethyl or /3-acetoxyethyl group for an original N-methyl radical. In the N-cetyl group the reverse was true. The halide salts and the nitrate all gave about the same activity. Organic anions usually lowered the activity of the compound. Cincinnati, Ohio

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The conversion of certain bromo substituted triphenylethylenes via cyano-and ethyl imidate hydrochloride derivatives to the corresponding guanyl (amidino) substituted triphenylethylenes has been accomplished. Unsubstituted amidines, N-alkyl-, , -dialkyland N,N'-dialkylamidines were prepared and the amidine group was incorporated into various heterocyclic substituents. Structural modifications of the triphenylethylene moiety gave rise to amidine derivatives of triphenylethane, triphenylhaloethylene and 9-benzalfluorene. When cis-trans isomerism was possible, separation of isomers could be effected by fractional crystallization of the intermediate nitriles. A number of the amidines exhibited anti-inflammatory and antifungal activities.