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Time resolved 3D-microscopy using DMD-arrays utilizes the principles of confocal microscopy. Application fitted patterns optimize optical imaging of reflective, transparent, and fluorescent objects. High spatial resolution is achieved simultaneously with high temporal resolution due to fast DMD control. This enables to visualize and track processes in vivo within living biocells.

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A new technique which combines the advantages of darkfield microscopy with those of confocal microscopy has been developed. The Massively Parallel Confocal darkfield method implemented on a DMD-based confocal platform allows for detection of non-fluorescing particles with dimensions below the diffraction limit. The lateral resolution and depth discrimination of three dimensional objects are improved relative to conventional darkfield microscopy.