Background: Iron deficiency anemia is common problem in children, though the oral iron therapy is the main stay of treatment, but most of children not responding to it due to non-compliance. So the parental iron therapy is the treatment of choice for it. Methods: Fifty children between the age group of 1-17 years of age were selected for this study diagnosed as iron deficiency anemia. Iron sucrose given by IV according to their weight and age. CBC performed before starting of study and after receiving Iron sucrose intravenously i.e. after 4, 10 and 30 days of iron sucrose. Results: Among the red cell indices, mean corpuscular volume and mean corpuscular haemoglobin in this study we got mark improvement in both the parameters along with improvement in PCV and finally increase in haemoglobin level. All the parameters having P value highly significant i.e. <0.001 along with minimal side effects. Conclusions: Iron sucrose can be safely used in children.

Inborn errors of metabolism (IEM) form a large group of genetic diseases involving defects in genes coding for enzymes, receptors, and cofactors in the metabolic pathways of small and large molecules. The present study is the comprehensive data analysis of the tandem mass spectrometry (TMS) and urine metabolic pattern for the diagnosis of IEMs by gas chromatography and mass spectrometry (GC/MS) in samples received for high-risk IEM screening. MethodsWe conducted a retrospective analysis of children diagnosed with IEMs presenting at the genetic clinic of Mahatma Gandhi Missions (MGM) Medical College, Aurangabad. This article summarizes retrospective data of 40 pediatric cases over a three-year period, diagnosed with small molecule IEM based on the standard testing criteria. ResultsOut of 40, 17 patients (42.5%) were found to have organic acidemias, four (10%) had fatty acid oxidation defects, six (15%) had disorders of aminoacidopathies, seven (17.5%) had mitochondrial diseases, and three (7.5%) had urea cycle defects. One patient in each group (2.5% each) had carbohydrate metabolism defects, purine metabolic defects, and neurotransmitter metabolic defects. ConclusionsThis clinico-etiological profile study has thrown light on the clinical features and natural course of many common and rare IEMs, and it may provide clinicians with a deeper understanding of these conditions, allowing for improved early diagnosis and treatment of these diseases. Because of the high degree of consanguinity and marriages in the same community, common as well as many rare inherited metabolic diseases were diagnosed and novel genetic variants were identified.

Introduction: Hepatitis A is a frequent form of hepatitis, especially in children. The changing epidemiology of the disease signifies the need for descriptive data concerning the clinical presentation and outcome of hepatitis A in children. The present study describes the clinical and biochemical profile of children with hepatitis A infection from a tertiary care center in the Aurangabad district of Maharashtra in Western India.Methods: One hundred patients between one and 18 years of age, presenting with symptoms/signs such as nausea, anorexia, vomiting, jaundice, abdominal pain, tender hepatomegaly, bleeding manifestations, or encephalopathy, were enrolled for the study. Serologically confirmed cases by detecting immunoglobulin M (IgM) antibodies against hepatitis A virus (HAV) were enrolled in the study. A detailed case proforma noted the clinical features and details such as age, gender, area, water supply, socioeconomic status, season, and biochemical parameters.Results: Most patients (45%) were among the age group of one to five years. Fever was reported in 96 (96%) patients, abdominal pain in 78 (78%) patients, dark-colored urine in 65 (65%) patients, vomiting in 47 (47%) patients, and anorexia in 63 (63%) patients. Icterus was found in 80 (80%) patients and hepatomegaly in 74 (74%) patients. In 61 (61%) patients, serum total bilirubin level on the first day was 1-4 mg/dL. Sixtyfive (65%) patients were using tap water as the water source, and the maximum number of patients (43%) came in August. Most patients belonged to the class IV group (61%) as per the modified Kuppuswamy classification.Conclusions: Most patients were 10 years or below, presenting predominantly with fever, abdominal pain, dark-colored urine, vomiting, and anorexia. Icterus and hepatomegaly were found in three-fourths or more of the patients. Around monsoon (June to September), there was the highest frequency of cases, and the socioeconomic status of most of the patients was within lower or upper-lower categories.

Original Research Article Background: An infant after birth goes transition from foetal circulation to neonatal circulation. Changes in ventilation and circulation occur during this time indicated by the changes in heart rate, respiratory rate and APGAR score. Aim: To form a normative data of pulse oxymetry readings in newborns at 1st, 5th, and 10th minute of life, in healthy term newborn. Material Methods: The study was conducted in tertiary care hospital in India during the period of 2 years. All the full term healthy newborns and no resuscitation required at birth were included in the study after taking voluntary informed consent of their parents. Predesigned semi-structured questionnaire was prepared based on the review of literature on pulse oximetry in healthy newborns Results: Total 2873 babies out of 4326 born were included in the study. Mean heart rate was 139 per minute at 1 minute which gradually reduced to 122 per minute at the end of 10 minutes. Mean respiratory rate was 45 per minute at 1 minute which gradually reduces to 40 per minute at the end of 10 minutes. Mean APGAR score was 9 at 1 minute which increased to 10 at the end of 10 minutes. Mean SpO2 was 67% at 1 minute which increased to 83% at the end of 5 minutes and 91% at the end of 10 minutes of life. Conclusion: the study concluded saturation trends didn't vary according to the gender, birth weight in term infants.

No abstract