Aim: Our aim was to automatically estimate the blood velocity in coronary arteries using cine X-ray angiographic sequence. Estimating the coronary blood velocity is a key approach in investigating patients with angina pectoris and no significant coronary artery disease. Blood velocity estimation is central in assessing coronary flow reserve.Methods and Results: A multi-step automatic method for blood flow velocity estimation based on the information extracted solely from the cine X-ray coronary angiography sequence obtained by invasive selective coronary catheterization was developed. The method includes (1) an iterative process of segmenting coronary arteries modeling and removing the heart motion using a non-rigid registration, (2) measuring the area of the segmented arteries in each frame, (3) fitting the measured sequence of areas with a 7° polynomial to find start and stop time of dye propagation, and (4) estimating the blood flow velocity based on the time of the dye propagation and the length of the artery-tree. To evaluate the method, coronary angiography recordings from 21 patients with no obstructive coronary artery disease were used. In addition, coronary flow velocity was measured in the same patients using a modified transthoracic Doppler assessment of the left anterior descending artery. We found a moderate but statistically significant correlation between flow velocity assessed by trans thoracic Doppler and the proposed method applying both Spearman and Pearson tests.Conclusion: Measures of coronary flow velocity using a novel fully automatic method that utilizes the information from the X-ray coronary angiographic sequence were statistically significantly correlated to measurements obtained with transthoracic Doppler recordings.

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SUMMARYQuantification of the hip cartilages is clinically important. In this study, we propose an automatic technique for segmentation and visualization of the acetabular and femoral head cartilages based on clinically obtained multi-slice T1-weighted MR data and a hybrid approach. We follow a knowledge based approach by employing several features such as the anatomical shapes of the hip femoral and acetabular cartilages and corresponding image intensities. We estimate the center of the femoral head by a Hough transform and then automatically select the volume of interest. We then automatically segment the hip bones by a self-adaptive vector quantization technique. Next, we localize the articular central line by a modified canny edge detector based on the first and second derivative filters along the radial lines originated from the femoral head center and anatomical constraint. We then roughly segment the acetabular and femoral head cartilages using derivative images obtained in the previous step and a top-hat filter. Final masks of the acetabular and femoral head cartilages are automatically performed by employing the rough results, the estimated articular center line and the anatomical knowledge. Next, we generate a thickness map for each cartilage in the radial direction based on a Euclidian distance. Three dimensional pelvic bones, acetabular and femoral cartilages and corresponding thicknesses are overlaid and visualized. The techniques have been implemented in C++ and MATLAB environment. We have evaluated and clarified the usefulness of the proposed techniques in the presence of 40 clinical hips multi-slice MR images.

Figure 1: A general overview of the various steps involved in the proposed approach (green panels) that bypasses the current methods used by the majority of the radiologists and state-of-the-art approaches based on thresholding and semi-automatic approaches (red panel).

Stress can a↵ect the brain functionality in many ways. As the synaptic vesicles have a major role in nervous signal transportation in synapses, their distribution in relationship to the active zone is very important in studying the neuron responses. We study the e↵ect of stress on brain functionality by statistically modelling the distribution of the synaptic vesicles in two groups of rats: a control group subjected to sham stress and a stressed group subjected to a single acute foot-shock (FS)-stress episode.We hypothesize that the synaptic vesicles have di↵erent spatial distributions in the two groups. The spatial distributions are modelled using spatial point process models with an inhomogeneous conditional intensity and repulsive pairwise interactions. Our results verify the hypothesis that the two groups have di↵erent spatial distributions.