Bone forming phenomenon is an exquisitely genetic programmed and dynamic process that occur from early embryo skeletal development to postnatal growth and culminating in the formation of highly variable and complex but perfect optimized structures. In this study the high resolution imaging techniques such as computerized tomography (CT) is used to obtain quantitative information about the progressive changes in three-dimensional (3D) skeletal morphology and density of rabbit thighbone during early embryo skeletal development to postnatal growth. Then the changes of the thighbone volume, shape and density during the bone growth process are evaluated by using the 3D images reconstruction method, and the growing direction of the thighbone structure is also evaluated. The effects of genetic and environmental complications to optimized skeletal patterns of bone are discussed.

Bone adaptive repair theory considers that the external load is the direct source of bone remodeling; bone achieves its maintenance by remodeling some microscopic damages due to external load during the process. This paper firstly observes CT data from the whole self-repairing process in bone defects in rabbit femur. Experimental result shows that during self-repairing process there exists an interaction relationship between spongy bone and enamel bone volume changes of bone defect, that is when volume of spongy bone increases, enamel bone decreases, and when volume of spongy bone decreases, enamel bone increases. Secondly according to this feature a bone remodeling model based on cross-type reaction-diffusion system influenced by mechanical stress is proposed. Finally, this model coupled with finite element method by using the element adding and removing process is used to simulate the self-repairing process and engineering optimization problems by considering the idea of bionic topology optimization.