Hepatitis C virus (HCV) and human T-lymphotropic virus type 1 (HTLV-1) coinfection occurs in many regions. However, few studies have focused on the natural history of HCV-induced liver disease in coinfected patients. To describe the clinical, epidemiological, and histopathological aspects of HTLV-1/HCV coinfection in Brazil. A cross-sectional study with 23 patients coinfected with HCV/HTLV. The control groups consisted of 21 patients monoinfected with HCV and 20 patients monoinfected with HTLV-1. The cytokine profiles (Th1 and Th2 cell responses), clinical, laboratory features, and histopathological aspects were examined. The control group for cytokine analysis validation consisted of patients monoinfected with HTLV, and a fourth group consisted of healthy blood donors. No anthropometric differences present between the three infected groups. We observed higher serum concentrations of IFN-γ in patients coinfected with HCV/HTLV-1 than those in HCV monoinfected patients. The HCV/HTLV-1 coinfected group also exhibited a higher degree of liver steatosis than the HCV monoinfected patients. Results suggest that HCV/HTLV-1 coinfection may result in a different pattern of HCV infection due to the immunologic disorders likely associated with HTLV-1, but there is no clear evidence of the HTLV role in the natural history of HCV infection. J. Med. Virol. 88:1967-1972, 2016. © 2016 Wiley Periodicals, Inc.

ResumoO objetivo é analisar os efeitos do Pilates solo e exercício resistido sobre medidas de adiposidade, circunferência abdominal (CA) e índice de massa corpórea(IMC). Trata-se de um ensaio clínico randomizado; a amostra foi constituída por 78 idosos, com idade mediana de 69 anos, sendo 89,7% do sexo feminino (mediana IMC=25,22 e CA= 98,0) e 10,3% do sexo masculino (mediana IMC=23,8 e CA=96,0), divididos por sorteio, em dois grupos, o grupo experimental (grupo Pilates-GP) e o grupo controle ativo (grupo resistido-GR). As variáveis independentes ativas estudadas foram o Pilates solo e o exercício resistido e as variáveis independentes atributivas correspondem a sexo, idade, IMC e CA. A análise estatística utilizada foi baseada em testes não paramétricos de Wilcoxon e Mann Whitney e para verificar a normalidade entre as variáveis foi utilizado o teste KS. A associação entre variáveis contínuas foi avaliada por meio do coeficiente de correlação de Spearman e os dados foram analisados pelo programa SPSS, versão 17.0; a probabilidade do valor inferior a 5% (p< 0,05) foi considerada estatisticamente significante. No grupo GP foi demonstrada a redução nas medidas de adiposidade IMC (p=0, 001) e CA (p= 0,001). A prática do Pilates solo promoveu redução significativa sobre as medidas de adiposidade em idosos. Palavras-chave: Terapia por Exercício. Envelhecimento. Obesidade central. AbstractThe objective is to examine the effects of soil Pilates and resistive exercise on measures of adiposity, waist circumference (WC) and body mass index (BMI). This is a randomized clinical trial; the sample consisted of 78 elderly patients, with a median age of 69 years, where 89.7% were female (median BMI = 25.22 and WC = 98.0) and 10.3% of males (median BMI = 23.8 and WC = 96.0), divided by lot into two groups, the experimental group (group Pilates-GP) and the active control group (group weathered-GR). The active independent variables studied were soil Pilates and resistive exercise and the independent variables correspond to attributive gender, age, BMI and WC. The statistical analysis used was based on nonparametric Wilcoxon and Mann Whitney tests and to ensure normality among the variables the KS test was used. Association among continuous variables was assessed by the Spearman correlation coefficient and the data were analyzed by SPSS software, version 17.0; lesser value probability at 5% (p <0.05) was considered statistically significant. In group GP the reduction was demonstrated in adiposity measures BMI (p = 0 001) and WC (p = 0.001). The practice of Pilates soil caused a significant reduction on measures of adiposity in the elderly patients.