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Passiflora species are well known for their common use in popular medicine for the treatment of several diseases, such as insomnia, anxiety, and hysteria, in addition to their anti-inflammatory, antioxidant, analgesic and antibacterial potential. However, few data about the chemical composition and the medicinal potential of in vitro derived materials are available. Therefore, the goal of this work was to compare, for the first time, the phytoconstituents of in vitro derived materials of four Passiflora species, and evaluate the antibacterial potential of their extracts against 20 Gram-positive and negative strains. Chromatographic analysis indicated the presence of saponins in roots extracts from all studied species, whereas leaf extracts presented both saponins and flavonoids. Extracts from leaves and roots of P. alata and P. foetida exhibited a selective inhibitory activity against B. thuringiensis and S. pyogenes, which might be related to the presence of a high concentration of secondary metabolites, including flavonoids and saponins.

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