No abstract

Congenital hemangiomas (CH) are benign vascular tumors that are typically defined as having had complete intrauterine development and to be fully formed at birth. They demonstrate several clinical and histologic features that are different from infantile hemangiomas (IH). One of the most characteristic differences is that CH are negative when stained for the immunohistochemical marker GLUT-1. 1 CH can be classified into three subgroups depending on their evolution: rapidly involuting CH (RICH), non-involuting CH (NICH), and partially involuting CH (PICH). Activating mutations in GNAQ and in GNA11 at amino acid position 209 have been identified in both RICH and NICH. Although PICH have not been studied at the molecular level, they are likely to have the same mutations. 2 Recently, several case series of CH with atypical presentations have been reported. 3-6 We present five cases of CH that demonstrated an unusual evolution.