No abstract

Método de estudo: trata-se de um estudo experimental, randomizado. Introdução: O processo de cicatrização é um conjunto dinâmico de alterações teciduais importantes que envolve inflamação e quimiotaxia. A Cordyline Dracaenóides Kunth, conhecida popularmente como Uvarana, é uma planta que contribui com o processo de cicatrização. Objetivo: Nesse contexto, o objetivo desse trabalho foi verificar os efeitos do extrato aquoso de Uvarana no processo cicatricial. Método: A amostra foi composta por 42 ratos da raça Rattus norvegicus, Wistar, divididos em quatro grupos experimentais: Grupo Controle Negativo, Grupo Controle Positivo, Grupo Uvarana e Grupo Fármaco, subdivididos em 3 e 7 dias. Os animais foram anestesiados com 80 mg/kg de Ketamina e 15 mg/kg de Xilazina e, em seguida, foram posicionados em decúbito ventral sobre uma prancha cirúrgica. Após isso, foi realizada a tricotomia da região dorsal e com uma lâmina de bisturi, foi feita uma incisão de 10 mm. Após a incisão, foi realizado o fechamento da ferida com fio de nylon número 5.0. Resultados: Observou-se que, no grupo em que foi aplicado o extrato aquoso de Uvarana, houve uma regeneração da epiderme com presença de crosta, o tecido dérmico apresentou células inflamatórias, a hipoderme teve intensa inflamação, a epiderme ficou mais espessa ao sétimo dia e a derme apresentou células regenerativas de colágeno e fechamento da cicatriz. Conclusão: Com base nesse estudo, pode-se concluir que o extrato aquoso de Uvarana é um método bastante eficaz no tratamento de lesões cutâneas e tem a capacidade de acelerar o processo de cicatrização.

No abstract

Alzheimer’s disease (AD) was defined as a neurodegenerative disorder, being more affected in the elderly. It is estimated that every 3.2 seconds a person in the world is affected by the high disease that rate in 2050 to 1 second. Therefore, research has been carried out on new therapeutic approaches, such as Transcranial Photobiomodulation and treatment based on antioxidants, such as Resveratrol. Therefore, the objective is to conduct a literature review on these two approaches and their effects on the treatment of AD. It was carried out according to the PRISMA recommendation and the articles were selected according to the years of publication (between 2015 and 2020) and extracted from the following databases: Science Direct, PubMed PMC, Scopus, PubMed NCBI, SciELO, LILACS, MEDLINE and PEDro. In several studies it has been reported that both therapies provide improvements at the molecular and behavioral level, recovering brain functions, acting in a neuroprotective way, improving quality of life, with few adverse effects and in a less invasive way. Thus, both treatments have numerous benefits that can be useful in the treatment of AD. However, there is a need for further research that includes interventions with greater specificity and control, so that they are defined as ideal doses and treatment protocols.

Background: Quercetin is a flavonoid widely found in plant kingdom and target of studies in pharmacological area due to its potent antinociceptive effect compared to analgesics used in conventional therapies. The aim was to evaluate its antinociceptive activity and antinociception mechanism. Methods: For this, 40 Norvegicus Wistar rats were used, divided into 4 groups: Q50 (treated with quercetin 50 mg/Kg), Q100 (treated with quercetin 100 mg/Kg), Q500 (treated with quercetin 500 mg/Kg) and Positive control (PC) without quercetin treatment), who were submitted through the pain induction methods by tail immersion and formalin in the first step to assess antinociceptive action and in the second step, tail immersion method receiving antagonists from opioid, cholinergic and nitric oxide - L-arginine to evaluate the action mechanism. Results: Quercetin antinociceptive activity was verified at the dose of 50 mg/kg and 100 mg/kg in tail immersion test after formalin injection, with better performance at the dose of 50 mg/kg. There were no statistically significant results in paw opening and capsaicin tests. Quercetin demonstrated a possible influence on opioid and cholinergic pathway, which was not observed on the nitric acid - L-arginine pathway in view of parameters tested. Conclusion: Quercetin performed the best antinociceptive activity at a dose 50 mg/kg and there was a possible influence on opioid and cholinergic pathways.