Study of transcranial photobiomodulation at 945-nm wavelength: anxiety and depression

Kerppers, Flávio Klinpovous; Santos, Kesia Maria Mangoni Gonçalves dos; Cordeiro, Maria Elvira Ribeiro; Pereira, Mário César da Silva; Barbosa, Danilo; Pezzini, André Alexandre; Cunha, Luiza Ferreira; Fonseca, Maiara; Bragnholo, Ketllin; Salgado, Afonso Shiguemi Inoue; Kerppers, Ivo Ilvan

doi:10.1007/s10103-020-02983-7

Cited by 27 publications

(21 citation statements)

References 37 publications

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“…Kerppers et al [30] -who examined transcranial photobiomodulation in an effort to heighten neural activity in anxious and/or depressed younger subjects did find this modality was able to stimulate brain activity. This was also the view of Maiello et al [22] and Cassano et al [44].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Gabel et al [29] who applied photo biomodulation to the back and thighs as an adjunct to physical therapy for chronic pain, also found the patients experienced improvements in concurrent depression. Kerppers et al [30] too, who studied the use of TPBM found this mode of intervention to decrease anxiety and depression, as well as increasing brain activity as a whole. Using an animal model of depression, Mohammed [31] similarly found laser irradiation to successfully ameliorate depression induced by reserpine, which was deemed indicative of the potentially beneficial anti-depressant effects of low-level infrared laser irradiation on tissues associated with depression in normal and healthy animal brain tissues.…”

Section: What the Research On Photobiomodulation Showsmentioning

confidence: 97%

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Photobiomodulation, Depression, Anxiety, and Cognition

Marks

2021

JARH

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Background Anxiety and depression are key barriers to healthy aging and greatly heighten the risk for many negative health issues that seriously impact life quality. Aim This mini review examines the potential of low level laser treatments or photobiomodulation therapy for ameliorating severe anxiety and depression in older adults. Methods and Procedures Articles that adressed the current topic of interest extracted from PUBMED and Google Scholar were carefully and presented in narrative form. Results Photobiomodulation therapy appears to be a safe efficacious modality for ameliorating various degrees of anxiety and depression and for improving cognition, and is supported by several well established mechanisms of action at the molecular, cellular, and tissue levels. Conclusion More research to examine who might benefit most from this form of therapy, and in what respect in this area of growing global concern and few intervention options is strongly warranted.

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Section: Discussionmentioning

confidence: 99%

Section: What the Research On Photobiomodulation Showsmentioning

confidence: 97%

Photobiomodulation, Depression, Anxiety, and Cognition

Marks

2021

JARH

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“…LED is a radiation of varying wavelength, not coherent and which is standing out in the field of medical treatment and phototherapy for being an alternative to the high cost of laser therapy [41]. The use of light with Low-intensity Laser Therapy or by Light-emitting Diode is called photobiomodulation [42] and among its functions, it is the stimulation of neural activity, that occurs through interaction with cytochrome c oxidase (unit IV of the mitochondrial electrons transport chain), which through a series of reactions, stimulates the ATP synthase enzyme to produce more ATP, improving brain function [27]. LED, however, emerged as an innovation in the field because it does not give off heat, is portable, is easy to apply, and is more durable when compared to other methods such as laser therapy (Figure 10) [27].…”

Section: Transcranial Photobiomodulationmentioning

confidence: 99%

Therapeutic Approaches for Alzheimer’s Disease: New Perspectives

Kerppers¹,

Hosni²,

Miri³

et al. 2022

Amyloidosis - History and Perspectives

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Alzheimer’s disease (AD) was defined as a neurodegenerative disorder, being more affected in the elderly. It is estimated that every 3.2 seconds a person in the world is affected by the high disease that rate in 2050 to 1 second. Therefore, research has been carried out on new therapeutic approaches, such as Transcranial Photobiomodulation and treatment based on antioxidants, such as Resveratrol. Therefore, the objective is to conduct a literature review on these two approaches and their effects on the treatment of AD. It was carried out according to the PRISMA recommendation and the articles were selected according to the years of publication (between 2015 and 2020) and extracted from the following databases: Science Direct, PubMed PMC, Scopus, PubMed NCBI, SciELO, LILACS, MEDLINE and PEDro. In several studies it has been reported that both therapies provide improvements at the molecular and behavioral level, recovering brain functions, acting in a neuroprotective way, improving quality of life, with few adverse effects and in a less invasive way. Thus, both treatments have numerous benefits that can be useful in the treatment of AD. However, there is a need for further research that includes interventions with greater specificity and control, so that they are defined as ideal doses and treatment protocols.

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“…Using a prolonged stress model to induce a PTSD-like phenotype in rats, the application of PBM to acupoints in both legs reduced anxiety-like symptoms and increased neural activation at the anterior cingulate cortex [ 21 ]. In two clinical pilot trials, transcranial PBM reduced depressive symptoms and demonstrated safety in human patients with major depressive disorder [ 22 , 23 ]. In a study examining the effects of transcranial PBM on generalized anxiety disorder, patients treated with PBM displayed significant reductions in measures of anxiety symptoms and had improvements in their quality of sleep [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Photobiomodulation prevents PTSD-like memory impairments in rats

Dong

Yang

et al. 2021

Mol Psychiatry

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A precise fear memory encoding a traumatic event enables an individual to avoid danger and identify safety. An impaired fear memory (contextual amnesia), however, puts the individual at risk of developing posttraumatic stress disorder (PTSD) due to the inability to identify a safe context when encountering trauma-associated cues later in life. Although it is gaining attention that contextual amnesia is a critical etiologic factor for PTSD, there is no treatment currently available that can reverse contextual amnesia, and whether such treatment can prevent the development of PTSD is unknown. Here, we report that (I) a single dose of transcranial photobiomodulation (PBM) applied immediately after tone fear conditioning can reverse contextual amnesia. PBM treatment preserved an appropriately high level of contextual fear memory in rats revisiting the “dangerous” context, while control rats displayed memory impairment. (II) A single dose of PBM applied after memory recall can reduce contextual fear during both contextual and cued memory testing. (III) In a model of complex PTSD with repeated trauma, rats given early PBM interventions efficiently discriminated safety from danger during cued memory testing and, importantly, these rats did not develop PTSD-like symptoms and comorbidities. (IV) Finally, we report that fear extinction was facilitated when PBM was applied in the early intervention window of memory consolidation. Our results demonstrate that PBM treatment applied immediately after a traumatic event or its memory recall can protect contextual fear memory and prevent the development of PTSD-like psychopathological fear in rats.

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Study of transcranial photobiomodulation at 945-nm wavelength: anxiety and depression

Cited by 27 publications

References 37 publications

Photobiomodulation, Depression, Anxiety, and Cognition

Photobiomodulation, Depression, Anxiety, and Cognition

Therapeutic Approaches for Alzheimer’s Disease: New Perspectives

Photobiomodulation prevents PTSD-like memory impairments in rats

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