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Glycoside extraction suffers from substantial yield loss of all illudane glycosides and indigenous pterosins in all sample pre-treatments studied relative to fresh frond material.

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Blakiella bartsiifolia (S.F. Blake), an endemic and rare high altitude plant of the northern Andes, appears well adapted to the prevailing harsh environment owing in part to a thick glandular trichome cover. From foliar exudates, two new clerodanes, 15,16-epoxy-2-hydroxy-3,13(16),14-clerodatrien-20-oic acid (bartsiifolic acid) (2) and Z-15,16-dihydroxy-3,13-clerodien-20-oic acid (barthydrolic acid) (3), were isolated in addition to the known junceic acid (1). In addition, three new alicyclic furanoditerpenes: 1,20-epoxy-1,3(20),6(E),10(E),14-phytapentaen-18-methyl-19-oic acid (blakielic acid) (4), 1,20-epoxy-1,3(20),10(E),14-phytapentaen-18-methyl-19-oic acid (blakifolic acid) (5) and 1,20-epoxy-1,3(20),6,14-phytatetraen-19-methyl-18-oic acid (dihydrocentipedic acid) (6) were obtained in minor quantity. Seed germination and plantlet growth bioassays on Allium cepa and Lactuca sativa to monitor bioactivity during isolation procedures revealed compounds 1-3 with substantial inhibition comparable with synthetic linuron.