Objetivo: Verificar e comparar a adesão, satisfação e experiência de mulheres em programa de telemonitoramento em fisioterapia após o câncer de mama. Método: Estudo quali-quantitativo com 10 participantes, alocadas por meio de sorteio para os grupos de telemonitoramento síncrono e assíncrono. A adesão foi avaliada pela frequência de execução dos exercícios. A satisfação, por duas perguntas com graduação de 0 a 10, e a experiência, por meio de perguntas abertas. Os dados quantitativos foram analisados no software SPSS e a interpretação dos dados qualitativos por meio da análise temática descrita por Braun e Clarke. Resultados: A adesão dos grupos síncrono e assíncrono foi de 95,5% e 93,3%, respectivamente. A satisfação do grupo síncrono apresentou média de 9,8 e do grupo assíncrono, média de 9,9. A experiência de ambos os grupos foi relatada positivamente. Conclusão: De acordo com este estudo piloto, mulheres pós-câncer de mama demonstraram alta taxa de adesão, alto grau de satisfação e relatos de experiências positivas em programa de telemonitoramento fisioterapêutico, tanto síncrono, quanto assíncrono. O telemonitoramento foi uma modalidade bem aceita entre as pacientes pós-tratamento do câncer de mama e pode ser desempenhado não somente durante a pandemia da Covid-19, mas como uma alternativa viável de reabilitação.
Zur Therapie fortgeschrittener Mammakarzinome wird erfolgreich der monoklonale Antikörper Trastuzumab (Herceptin) eingesetzt. Der Mechanismus beruht auf der Blockierung der Funktion des Onkogens HER-2/neu. Aktuelle Studien untersuchen die Effektivität von Herceptin auch in der adjuvanten Situation. In der vorliegenden Arbeit untersuchten wir im Mausmodell das Remissionsverhalten von Tumoren nach gezieltem Abschalten der Expression von HER-2/neu in Abhängigkeit von der Gröûe der Tumoren. Damit sollten tumorbiologische Grundlagen für den Einsatz von Herceptin in der adjuvanten Situation aufgezeigt werden. Material und Methoden: HER-2/neu transfizierte NIH3T3-Zellen wurden subkutan in die dorsale Hautpartie von 52 Nacktmäusen gespritzt. Für die Kontrolle des Tumorwachstums in vivo wurde ein Modell zur kontrollierten Expression von HER-2/neu verwendet, das TET-OFF-System. Mit diesem System wurde die Expression von HER-2/neu wahlweise durch die Zugabe bzw. den Entzug von Anhydrotetracyclin ab-oder angeschaltet, wobei vier Behandlungsgruppen gebildet wurden, die sich bezüglich der Tumorgröûe bei Behandlungsbeginn und der Dauer der Behandlung mit Anhydrotetracyclin unterschieden. Der Verlauf des Tumorwachstums wurde im MRT verfolgt.
Introduction: Breast is cancer is the most common cancer in women, and the various procedures and treatments performed after diagnosis can trigger physical symptoms. The objective was to verify the influence of pain on the functionality of the upper limbs (UL) in women after breast cancer surgery, in two postoperative periods. Methods: This is an exploratory cross-sectional study with women evaluated postoperatively at 6 (N=126) and 12 months (N=74). The outcomes were assessed using a Pain Body Diagram, a Numerical Pain Scale, and Quick-DASH. Multiple linear hierarchical regression analysis was performed adjusting for pain, clinical (radiotherapy, chemotherapy and axillary intervention), and sociodemographic variables (age, education level, ethnic), p <0.05. Results: Participants in the 6-month group had a similar functionality score (mean=27, SD=18.9) compared to the 12-month group (mean=24.6, SD=19.1). In both postoperative periods, the intensity of pain was classified as moderate, and the anterior region of the trunk was the most affected. Pain was more prevalent at 6 months (71.4%) compared to 12 months PO (57.3%), but the intensity of pain in the anterior and lateral trunk for the 12 months PO group was significantly higher compared to those at 6 months PO (p<.05). Among the variables included in the model, only pain was associated with worse functionality scores both at 6 (R²=0.23) and at 12 months postoperatively (R²=0.31). Conclusion: Pain was the most important factor influencing upper limb functionality. These results can guide professionals to foster pain control strategies to improve upper limb functionality.
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