Objective. Develop a system to classify frequency of dissociation in CMD/bruxers, and evaluate the use of antianxiety and antidepressant drugs. Method. History of sign/symptoms, clinical examination, muscle /joint palpation, criteria for Craniomandibular disorders (CMDs), severities of bruxing behavior, and the Dissociative Experience Scale (DES), in 243 CMD individuals and 43 controls. A system with scores from 0-10%, 11-19%, 20-29%, 30-39% and 40% or higher was used to classify CMD individuals and controls as presenting no, mild, moderate, severe and very severe dissociation. Results. 73,3% and 30,2% CMD and non CMD controls subjects, respectively, demonstrated some degree of dissociation (p<0.0001). Mild and moderate dissociation (55% , 24,2%) occurred more frequently as compared to severe and very severe dissociation (11,8, 9%), in the CMD group. CMD and dissociation individuals demonstrated greater use of antianxiety but not antidepressant drugs than those without ( 31%, 11,4%, p=0.04) and (62%, 40%, p=0,32). Use of antianxiety and antidepressant drugs increased with the severity of dissociation (p=0,009, p=0.04). Conclusions. Dissociation in CMD/bruxing behavior individuals varied greatly, mild and moderate dissociation occurred more frequently, and antidepressants rather than antianxiety drugs were used more frequently in CMD and dissociation patients than in those CMD without dissociation.