No abstract

Orodispersible films (ODFs) address the needs of pediatric and geriatric patients and people with swallowing difficulties due to fast disintegration in the mouth. Typically, they are obtained using the solvent casting method, but other techniques such as 3D printing and electrospinning have already been investigated. The decision on the manufacturing method is of crucial importance because it affects film properties. This study aimed to compare electrospun ODFs containing aripiprazole and polyvinyl alcohol with films prepared using casting and 3D printing methods. Characterization of films included DSC and XRD analysis, microscopic analysis, the assessment of mechanical parameters, disintegration, and dissolution tests. Simplified stability studies were performed after one month of storage. All prepared films met acceptance criteria for mechanical properties. Electrospun ODFs disintegrated in 1.0 s, which was much less than in the case of other films. Stability studies have shown the sensitivity of electrospun films to the storage condition resulting in partial recrystallization of ARP. These changes negatively affected the dissolution rate, but mechanical properties and disintegration time remained at a desirable level. The results demonstrated that electrospun fibers are promising solutions that can be used in the future for the treatment of patients with swallowing problems.

No abstract

Although anodic tungsten oxide has attracted increasing attention in recent years, there is still a lack of detailed studies on the photoelectrochemical (PEC) properties of such kind of materials grown in different electrolytes under various sets of conditions. In addition, the morphology of photoanode is not a single factor responsible for its PEC performance. Therefore, the attempt was to correlate different anodizing conditions (especially electrolyte composition) with the surface morphology, oxide thickness, semiconducting, and photoelectrochemical properties of anodized oxide layers. As expected, the surface morphology of WO3 depends strongly on anodizing conditions. Annealing of as-synthesized tungsten oxide layers at 500 °C for 2 h leads to obtaining a monoclinic WO3 phase in all cases. From the Mott-Schottky analysis, it has been confirmed that all as prepared anodic oxide samples are n-type semiconductors. Band gap energy values estimated from incident photon−to−current efficiency (IPCE) measurements neither differ significantly for as−synthesized WO3 layers nor depend on anodizing conditions such as electrolyte composition, time and applied potential. Although the estimated band gaps are similar, photoelectrochemical properties are different because of many different reasons, including the layer morphology (homogeneity, porosity, pore size, active surface area), oxide layer thickness, and semiconducting properties of the material, which depend on the electrolyte composition used for anodization.

A simple photoelectrochemical (PEC) sensor based on non-modified nanostructured anodic TiO2 was fabricated and used for a rapid and sensitive detection of glucose. The anodic TiO2 layers were synthesized in an ethylene glycol-based solution containing NH4F (0.38 wt.%) and H2O (1.79 wt.%) via a three-step procedure carried out at the constant voltage of 40 V at 20 °C. At the applied potentials of 0.2, 0.5, and 1 V vs. saturated calomel electrode (SCE), the developed sensor exhibited a photoelectochemical response toward the oxidation of glucose, and two linear ranges in calibration plots were observed. The highest sensitivity of 0.237 µA µmol−1 cm−2 was estimated for the applied bias of 1 V. The lowest limit of detection (LOD) was obtained for the potential of 0.5 V vs. SCE (7.8 mM) with the fastest response at ~3 s. Moreover, the proposed PEC sensor exhibited relatively high sensibility, good reproducibility, and due to its self-cleaning properties, a good long-term stability. Interfering tests showed the selective response of the sensor in the presence of urea and uric acid. Real-life sample analyses were performed using an intravenous glucose solution, which confirmed the possibility of determining the concentration of analyte in such types of samples.