Apocrine cystic lesions with true papillary projections should be referred to as AC rather than AH, to emphasize the proliferative adenomatous growth and depicted by their frequency of cytological atypia and high mitotic activity. Furthermore, we suggest complete excision of AC that are proliferative tumors.

The current World Health Organization classification of conjunctival melanocytic proliferations divides them into conjunctival nevi and invasive melanoma but, in contrast to other anatomic sites, does not recognize melanoma in situ. All atypical intraepithelial conjunctival proliferations are included in a heterogeneous category designated as primary acquired melanosis (PAM) with atypia. We performed clinicopathologic analysis of 29 cases of PAM with atypia. On the basis of histologic features and frequency of association with invasive melanoma and metastases, we were able to divide our cases into 2 histologic groups. The low-risk group (13 cases) included lesions composed of small to medium size melanocytes with high nuclear to cytoplasmic ratio and small to medium size hyperchromatic nuclei devoid of nucleoli showing predominantly single cell lentiginous growth pattern. Invasive melanoma occurred in only 2 cases from this group. None of these lesions metastasized. The second, high-risk group (16 cases), showed increased frequency of association with invasive melanoma (15/16 cases, 94%) and metastases (4/16 cases, 25%). These lesions were more heterogeneous architecturally but were all composed of melanocytes showing various degrees of epithelioid features such as abundant cytoplasm, vesicular nuclei, or prominent nucleoli. In 4 cases discrete areas showing high-risk and low-risk features were identified. All 4 lesions were associated with invasion. Our findings offer a practical approach for prognostically useful subclassification of PAM with atypia, which emphasizes cytologic features of intraepithelial conjunctival melanocytic proliferation.

The perceptual span, which is the visual area providing useful information to a reader during eye fixation, has been well investigated among native or first language (L1) readers, but not among second language (L2) readers. Our goal was to investigate the size of the perceptual span among Japanese university students who learn English as a foreign language (EFL) to investigate parafoveal processing during L2 reading. In an experiment using the gaze-contingent moving window paradigm, we compared perceptual span between Japanese EFL readers (N = 42) and native English L1 readers (N = 14). Our results showed that (1) the EFL readers had a smaller perceptual span than the L1 readers did, and (2) the facilitating effect of parafoveal information was greater for faster EFL readers than it was for slower EFL readers. These findings provide evidence that EFL readers can only utilize little parafoveal information during fixation when compared with L1 readers.