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Hospitals, as the main customers of medications, typically adopt conservative inventory control policies by keeping large quantities of drugs in stock. Given the perishable nature of medications, such strategies lead to the expiration of excess inventory in the absence of patients' demand. Consequently, producers are faced with governmental penalties and environmental reputation forfeit due to the negative impact that disposing expired medications pose to the environment. This article aims to improve the sustainability of a pharmaceutical supply chain using a real case study. An analytical model is proposed to explore the effect of implementing a Vendor-Managed Inventory (VMI) system in minimizing the quantity of the expired medications at hospitals. Further, a set of Monte-Carlo simulation tests are conducted to investigate the robustness of the VMI model under demand uncertainty. Experimental results on a real case study under deterministic demand show the efciency of the VMI model in eliminating the amount of expired medications without compromising customer's satisfaction. The results also demonstrate that the safety stock (SS) level and the capacity assigned to the customer are crucial factors in the overall cost of the pharmaceutical supply chain (PSC). The PSC cost could be reduced by 19% when reducing the SS level by 50%. Moreover, the producer is recommended to increase the capacity assigned to the customer by a factor of 1.5 so as to fully satisfy the customer's demand. Finally, the simulation results conrm the efciency and robustness of embracing a VMI system under random demand scenarios. More precisely, zero amount of expired medications is obtained in 93% of cases. Thus, adopting this strategy could minimize drug wastage and ultimately improve the reputation of the producer in the market in terms of implementing Lean and sustainable practices.

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