Calabria Region supports the choices of cities in terms of urban mobility in an integrated approach by a high level of cooperation, coordination and consultation between the different levels of government and relevant authorities. Urban mobility includes city logistics. The Region supports all interventions according to European directions, as Sustainable Urban Mobility Plans, leaving from urban logistics topic. In particular, regional administration supports local administrations to realize an efficient urban logistic by the implementation of Regional Transport Plan Measure 2.5 City Logistics, in the general framework of urban planning. The aim is to improve sustainability and livability of cities pursuing national and international social, economic and environmental goals. Calabria Region have implemented a programming and execution process carried out by regional offices on city logistics. The programming process is finalized at Implementation Program definition and its approval by regional executive government. The Implementation Program indicates the city logistic measures and their realization procedures. The execution process is finalized at Call definition. The aim of Call is to finance design and realization of city logistic projects in all the cities of Calabria that satisfy some constraints. In this paper, programming and execution actions on city logistics of Calabria Region are presented.