The liver is the body’s most critical organ that performs vital functions. Hepatic disorders can affect the physiological and biochemical functions of the body. Hepatic disorder is a condition that describes the damage to cells, tissues, structures, and functions of the liver, which can cause fibrosis and ultimately result in cirrhosis. These diseases include hepatitis, ALD, NAFLD, liver fibrosis, liver cirrhosis, hepatic failure, and HCC. Hepatic diseases are caused by cell membrane rupture, immune response, altered drug metabolism, accumulation of reactive oxygen species, lipid peroxidation, and cell death. Despite the breakthrough in modern medicine, there is no drug that is effective in stimulating the liver function, offering complete protection, and aiding liver cell regeneration. Furthermore, some drugs can create adverse side effects, and natural medicines are carefully selected as new therapeutic strategies for managing liver disease. Kaempferol is a polyphenol contained in many vegetables, fruits, and herbal remedies. We use it to manage various diseases such as diabetes, cardiovascular disorders, and cancers. Kaempferol is a potent antioxidant and has anti-inflammatory effects, which therefore possesses hepatoprotective properties. The previous research has studied the hepatoprotective effect of kaempferol in various hepatotoxicity protocols, including acetaminophen (APAP)-induced hepatotoxicity, ALD, NAFLD, CCl4, HCC, and lipopolysaccharide (LPS)-induced acute liver injury. Therefore, this report aims to provide a recent brief overview of the literature concerning the hepatoprotective effect of kaempferol and its possible molecular mechanism of action. It also provides the most recent literature on kaempferol’s chemical structure, natural source, bioavailability, and safety.

Background:Recently, emulgel has emerged as a potential hydrophobic drug delivery method. Therefore, this study aims to evaluate the phytochemical content of Oryza sativa extract and develop an emulgel formulation using Carbapol 940 as a gelling agent. Materials and Methods: The emulsion was placed in a gel basis after preparation and the formulations were evaluated for their rheology, pH, spreading coefficient, stability, and sun protection factor. Then, phytochemical analysis of O. sativa extract was used to determine the presence of alkaloids, flavonoids, polyphenols, quinones, monoterpenoids, and sesquiterpenoids, as well as triterpenoids and steroids. Results: The entire formulations of O. sativa emulgel extract filled the emulgel formulation criteria. Furthermore, O. sativa emulgel protects against UV radiation, as indicated by the SPF value in each formulation, which increases as the dose of O. sativa extract increases. Based on the results, formulations 2 and 3 have an SPF of 5.71±0.063 and 16.07±0.072, respectively. These suggest that they both fill the Indonesian National Standard, which requires a sunscreen preparation with a minimum of four protection. Conclusion: Consequently, O. sativa emulgel extract can serve as a novel sunscreen agent against UV radiation. However, further study is required to ascertain the mechanism of action of the active chemicals found in O. sativa that function as an antioxidant and give protection against UV radiation.

Indonesia has the world's country second largest forest biodiversity, with 28,000 plant species, of which 2,500 species, including Castanopsis costata, commonly known as "Cep-cepan", are used as medicine. 9-10 C. costata belongs to the Fagaceae family and has been known to exhibit therapeutic activities, for instance, anti-fever, digestive issue alleviation, and analgesic properties. 11 According to previous studies, C. costata exhibits numerous biological properties, including antioxidant activity, 12 antiinflammatory activity, 13 and antimalaria activity. 10 Furthermore, in North Sumatra, the plant is frequently used to treat diabetes, however, there are no studies confirming this practice. Therefore, this study aims to evaluate the anti-diabetic activity of the extract and fractions of C. costata leaves. MATERIALS AND METHODS Plant material collection and preparationAbout 10 kg of fresh C. costata leaves were collected in Pancur Batu Districts, North Sumatra, and transported to the Central Laboratory, Buana Perjuangan Karawang University for cleaning, air drying, milling, and extraction. The Herbarium Unit of the Department of Biology, Faculty of Mathematics and Science, Universitas Padjadjaran later recognized the plant as C. costata (Code: 219/HB/04/2017). Reagents and instrumentsThis study induced diabetes in Swiss albino mice using alloxan monohydrate (Sigma Chemical

Castanopsis costata (C.costata) leaves were empirically used by people in North Sumatera, Indonesia, as an antioxidant dietary supplement. However, its pharmacological effect has not been scientifically explored. The purpose of this study was to identify the secondary metabolites and antioxidant activity of C. costata. The leaves were cold extracted with methanol. The secondary metabolites were determined using thin layer chromatography. Its antioxidant activity was investigated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The results showed that methanol extract of C. costata leaves consisted of alkaloids, flavonoids, glycosides, anthraquinone glycosides, tannins and triterpenoids. The methanol extract of C. costata leaves showed comparable antioxidant activity with vitamin C, IC 50 35.56 µg/ ml and 14.17 µg/ml, respectively.

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