Scabies is a skin disease that is still a problem with 200 million cases in 2015 in the world. Reducing the incidence of scabies, the understanding of scabies is essential since knowledge is a factor that will determine behaviour. This study aims to analyse the relationship between scabies and the level of knowledge of students in a religious boarding school. This study was a cross-sectional study with analysis using the Fisher Exact test. The incidence of scabies gathered through physical examination, and the diagnosis of scabies based on the cardinal sign such as diffuse itching presents along with either lesion in two regular spots or itchiness is present in another household member. The student's level of knowledge accessed using a questionnaire. Results showed that the incidence of scabies was quite high although most of the students have a good level of knowledge. The results show that not only knowledge but behaviour plays a vital role in one's hygiene. It concluded that there was no relationship between the level of knowledge and the incidence of scabies.
Case reports of a chronic diabetic wound treated topically using coffee powder. It is a useful dressing that changed every week with keep dry without repeated manipulation to wound bed to protect the new cell growth. It claimed to be a safe procedure to preserve the vulnerable cells in wound bed by the coffee powder producing the best healing with acceptable wound scar.
There are no effective standard treatments for unresectable stage of liver cancer have been established. These insights lead the pursuit of targeted therapeutic strategies for reactivating apoptosis to eradicate cancer cells. It was hypothesized that active compound in the soursop leaves will be able to induce apoptosis. Objective of the study is to explore the role of novel soursop leaves active compound (SF-1603) in apoptosis induction to find a new agent for liver cancer therapy. This study was use HepG2 cell line culture seeded in DMEM / F12. There were control group and 3 intervention group given SF-1603 with different concentration. Apoptosis detection was done using Terminal deoxynucleotidyl Transferase-mediated dUTP Nick End Labeling (TUNEL) method. Statistical analyses were conducted using linear regression. The result showed the cells undergoing apoptosis in the control group less than treatment groups. There was a strong positive correlation (r=0.847) between the rate of apoptosis and a concentration of SF-1603, reflected the apoptotic effect with a dose-dependent manner. The study conclude, the novel soursop leaves active compound SF-1603 had the strong ability to induce apoptosis on liver cancer cell line culture, so it can be used as a candidate for new agent for liver cancer therapy.
Bajakah wood contains phenolic compounds, flavonoids, tannins, and saponins with anticancer activity. The discovery and development of new drugs require several stages. In the process, there are many possibilities of adding other substances to form new active substances or as solvents that allow drug preparations to be doubtful of halalness. Hence, it is necessary to analyze the critical point of halal ingredients. The purpose of this study was to determine the characteristics of the nanoparticles of bajakah wood (Spatholobus littoralis Hassk.) and to test the anticancer activity in several cancer cell cultures, as well as to analyze the critical point of halalness of the material. This research method is a composition test using chromatography and anticancer activity test using MTT. Analysis of the critical point of halal materials using hazard analysis critical control point (HACCP). The research was carried out at the Indonesian Engineering Nanotechnology Laboratory South Tangerang and the UGM Integrated Laboratory Sleman in July–December 2020. The results showed that bajakah wood nanoparticles contained pure water as a solvent, viscosity 0.08878 cP, scattering intensity 1.1059 cps, diameter 176.1+/−43.7 (nm). Cytotoxic test results showed IC50 against cell culture MCF7 1,063.28 (±114.98) g/mL, HepG2 53.34 (±0.35) g/mL, T47D 150.63 (±8.44) g/mL, WiDR 114.38 (±7.82) μg/mL, HTB 97.50 (±3.49) μg/mL, HeLa 182.95 (±36.22) μg/mL, and Vero 710.10 (±106.46) μg/mL. This study concludes that bajakah wood nanoparticles are not critical in terms of halal ingredients. At the same time, their anticancer activity is weak against breast cancer and uterine cervical cancer, medium categories against liver cancer and lung cancer, and is not toxic to normal cells. ANALISIS TITIK KRITIS KEHALALAN NANOPARTIKEL KAYU BAJAKAH (SPATHOLOBUS LITTORALIS HASSK.) SEBAGAI AGEN ANTIKANKERKayu bajakah mengandung senyawa fenolik, flavonoid, tanin, dan saponin yang memiliki aktivitas antikanker. Penemuan dan pengembangan obat baru memerlukan beberapa tahapan. Dalam prosesnya terdapat banyak kemungkinan penambahan zat lain untuk membentuk zat aktif baru atau sebagai pelarut yang memungkinkan sediaan obat diragukan kehalalannya. Oleh sebab itu, perlu dilakukan analisis titik kritis kehalalan bahan. Tujuan penelitian ini mengetahui karakteristik sediaan nanopartikel kayu bajakah (Spatholobus littoralis Hassk.) dan menguji aktivitas antikanker pada beberapa kultur sel kanker, serta menganalisis titik kritis kehalalan bahan. Metode penelitian ini adalah uji komposisi menggunakan kromatografi dan uji aktivitas antikanker menggunakan MTT. Analisis titik kritis kehalalan bahan menggunakan hazard analysis critical control point (HACCP). Penelitian dilakukan di Laboratorium Nanovasi Rekayasa Indonesia Tangerang Selatan dan Laboratorium Terpadu UGM Sleman pada Juli–Desember 2020. Hasil penelitian menunjukkan sediaan nanopartikel kayu bajakah mengandung pelarut air murni, viskositas 0,08878 cP, scattering intensity 1,1059 cps, berdiameter 176,1+/−43,7 (nm). Hasil uji sitotoksik menunjukkan IC50 terhadap kultur sel MCF7 1.063,28 (±114,98) μg/mL, HepG2 53,34 (±0,35) μg/mL, T47D 150,63 (±8,44) μg/mL, WiDR 114,38 (±7,82) μg/mL, HTB 97,50 (±3,49) μg/mL, HeLa 182,95 (±36,22) μg/mL, dan Vero 710,10 (±106,46) μg/mL. Kesimpulan penelitian ini bahwa nanopartikel kayu bajakah bersifat tidak kritis dalam kehalalan bahan. Selain itu, aktivitas antikankernya lemah terhadap kanker payudara dan kanker serviks uteri, sedang terhadap kanker hati dan kanker paru, serta tidak toksik pada sel normal.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.