These results suggest that sequence variations in SLC1A1 are associated with susceptibility to AAP-induced OC symptoms. This is the first published pharmacogenetic study on this phenomenon and provides preliminary evidence of the involvement of glutamatergic neurotransmission in the pathogenesis of AAP-induced OC symptoms.

BackgroundIn light of the increased suicide rate in Korea, it has become important for researchers to examine the various factors associated with it. The purpose of this study is to compare and analyze the difference between suicide attempters and completers in terms of the suicide methods used and the lethality of these methods. In addition, we investigated certain demographic factors that are associated with the choice of suicide method by evaluating their lethality.FindingThe most frequently used methods of suicide were different in the two groups of attempters and completers. Drug poisoning was the most frequent method in suicide attempters, whereas hanging was the most common method among suicide completers. Drug poisoning, stabbing, and other chemical poisoning were evaluated as relatively non-lethal compared to other suicide methods. While about 70.0% of the suicide attempters used relatively non-lethal methods, almost all suicide completers used lethal methods, based on our classification of the lethality of the method. In terms of gender, males used more lethal methods of suicide.ConclusionsSuicide completers’ choice of suicide methods are different from those of suicide attempters and tend to be more lethal. Interventions to restrict access to more lethal suicidal methods could be a useful strategy to reduce the suicide rates in South Korea.

study also found that changes in appetite and eating behavior were significantly associated with weight gain during the early phase of antipsychotic treatment.There are some limitations of this study. First, although the 3 index medications used in the current study could cover wide range of antipsychotics' propensities to induce weight gain, it is hard to generalize the current result to all antipsychotic-related weight gain. Second, we administered the DR-EBQ retrospectively, and some recall bias might have affected the results.Within the aforementioned limitations, the current study's findings suggest that changes in patients' eating behavior while taking antipsychotics seem to be highly associated with weight gain and that prominent characteristics of these changes include increased hunger sensation and loss of control over food craving, especially for sweets. Researchers could adopt the eatingbehavior change assessed by the DR-EBQ as a mediating factor in future studies exploring the biological mechanisms of antipsychotic-induced weight gain. Further studies to revise and upgrade the DR-EBQ for use in diverse clinical and biological studies are also warranted. ACKNOWLEDGMENTS

No abstract

No abstract