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BackgroundTrimad is an Ayurvedic polyherbal formulation consisting of tubers of Mustaka (Cyperus rotundus), fruits of Vidanga (Embelia ribes) and roots of Chitraka (Plumbago zeylanica). It is recommended in Ayurveda for the management of obesity. However, there is no documented evidence about its safety and efficacy. Hence, as a first step, we carried out a survey to find out its usage by Ayurvedic physicians and their personal clinical experiences while using the formulation.MethodologyA questionnaire was designed which included questions regarding the usage, dosage, formulation, safety and tolerability of Trimad. After obtaining Ethics Committee permission, the questionnaire was administered to 86 physicians. Out of 86, the data obtained from 70 physicians who filled the complete information, was analyzed. The data are presented as percentages.ResultsSixty seven percentage physicians were found to use Trimad for management of obesity. The commonly used form of Trimad was churna administered along with luke warm water as an adjuvant. The criteria for selection of drug informed by the physicians were Ayurvedic signs & symptoms followed by conventional anthropometry. The average efficacy rating for Trimad on scale of 1–10 was found to be 5.ConclusionThe survey revealed that Trimad is being used by large number of Ayurvedic physicians for the management of obesity.

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The objective of the present study was to evaluate aqueous extract of Trimad for its in vitro antioxidant activity. A battery of in vitro biochemical tests such as total phenol content, ferric reducing power, ABTS [2, 2 azino-bis (3-ethylbenzothiazoline-6-sulphonic acid)] scavenging activity and Lipid peroxidation inhibitory activity was used. The total phenol content of Trimad was found to be 279.5 mg/g dry mass. In case of DPPH scavenging activity, Trimad was found to be more potent than ascorbic acid at all given concentrations. It also showed significant ferric reducing potential (0.110% at 20μg/ml) and ABTS scavenging activity (31% at 80μg/ml). Trimad however showed very minimal (4.754% at 100μg/ml) lipid peroxidation activity. Our findings indicate promising antioxidant activity of Trimad extract however it needs further attention for its effective use in both modern and traditional system of medicines

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